• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Plant Science >The functional scope of plant microRNA-mediated silencing
【24h】

The functional scope of plant microRNA-mediated silencing

机译：植物microRNA介导的沉默的功能范围

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Deep sequencing has identified a complex set of plant miRNAs that potentially regulates many target genes of high complementarity. Furthermore, the discovery that many plant miRNAs work through a translational repression mechanism, along with the identification of noncanonical targets, has encouraged bioinformatic searches with less stringent parameters, identifying an even wider range of potential targets. Together, these findings suggest that any given plant miRNA family may regulate a highly diverse set of mRNAs. Here we present evolutionary, genetic, and mechanistic evidence that opposes this idea but instead suggests that families of sequence-related miRNAs regulate very few functionally related targets. We propose that complexities beyond complementarity impact plant miRNA target recognition, possibly explaining the current disparity between bioinformatic prediction and functional evidence.
机译：深度测序已鉴定出一组复杂的植物miRNA，它们可能调控许多具有高互补性的靶基因。此外，许多植物miRNA通过翻译抑制机制发挥作用的发现以及对非经典靶标的发现，促进了生物信息学搜索的严格性参数降低，从而确定了更大范围的潜在靶标。总之，这些发现表明，任何给定的植物miRNA家族均可调节高度多样化的mRNA。在这里，我们提出了反对这一想法的进化论，遗传学和机制学证据，而是表明与序列相关的miRNA家族调节的功能相关靶标很少。我们提出，超出互补性的复杂性会影响植物miRNA靶标的识别，可能解释了生物信息学预测与功能证据之间的当前差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号