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首页> 外文期刊>Trends in Plant Science >Paralogue Interference Affects the Dynamics after Gene Duplication
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Paralogue Interference Affects the Dynamics after Gene Duplication

机译:Paralogue干扰影响基因复制后的动力学。

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摘要

Proteins tend to form homomeric complexes of identical subunits, which act as functional units. By definition, the subunits are encoded from a single genetic locus. When such a gene is duplicated, the gene products are suggested initially to cross-interact when coexpressed, thus resulting in the phenomenon of paralogue interference. In this opinion article, we explore how paralogue interference can shape the fate of a duplicated gene. One important outcome is a prolonged time window in which both copies remain under selection increasing the chance to accumulate mutations and to develop new properties. Thereby, paralogue interference can mediate the coevolution of duplicates and here we illustrate the potential of this phenomenon in light of recent new studies.
机译:蛋白质趋于形成相同亚基的同源复合物,这些亚基充当功能单元。根据定义,亚基是从单个遗传基因座编码的。当这样的基因被复制时,建议基因产物最初在共表达时发生交叉相互作用,从而导致旁系干扰现象。在这篇见解文章中,我们探讨了旁系干扰如何影响复制基因的命运。一个重要的结果是延长了时间范围,其中两个副本都处于选择状态,从而增加了积累突变和开发新特性的机会。因此,旁系干扰可以介导重复项的协同进化,在这里我们根据最近的新研究来说明这种现象的可能性。

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