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Delivery of small interfering RNA. A review and an example of application to a junction oncogene.

机译:传递小分子干扰RNA。结节致癌基因的应用综述和实例。

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摘要

RNA interference strategies using small interfering RNA is one of the most important discoveries in biology in recent years. This technology alongside antisense oligonucleotides is very promising and our group has focused its work on the targeting of junction oncogenes with these molecules. We have taken, as first example, papillary thyroid carcinoma. But there is a great need in delivery methods for these molecules in the treatment of cancers. Indeed, many studies have shown that small interfering RNA and antisense oligonucleotides are made efficient by various innovative delivery methods and, under these conditions, offer a powerful new therapeutic tool in cancer treatment.
机译:使用小分子干扰RNA的RNA干扰策略是近年来生物学上最重要的发现之一。与反义寡核苷酸一起使用的这项技术非常有前途,我们小组将工作重点放在与这些分子连接癌基因的靶向上。我们以甲状腺乳头状癌为例。但是,对于这些分子在癌症治疗中的递送方法有极大的需求。确实,许多研究表明,各种创新的递送方法使小分子干扰RNA和反义寡核苷酸变得高效,并且在这些条件下,为癌症治疗提供了强大的新治疗工具。

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