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首页> 外文期刊>Tumori. >Impact of delayed radiotherapy on local control in node-negative breast cancer patients treated with breast-conserving surgery and adjuvant radiotherapy without chemotherapy.
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Impact of delayed radiotherapy on local control in node-negative breast cancer patients treated with breast-conserving surgery and adjuvant radiotherapy without chemotherapy.

机译：保乳手术和无化疗辅助放疗的延迟阴性放疗对淋巴结阴性乳腺癌患者局部控制的影响。

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AIM AND BACKGROUND: To evaluate the effect of the surgery-radiotherapy interval (SRI) on local control in node-negative breast cancer patients treated with breast-conserving surgery and adjuvant radiotherapy without chemotherapy. METHODS: From February 1992 to January 2002, 171 patients with node-negative breast cancer underwent breast-conserving surgery and adjuvant radiotherapy without chemotherapy. The whole breast was irradiated up to 50.4 Gy in 28 fractions followed by a 10-Gy boost to the tumor bed. Forty-four patients received tamoxifen in addition to radiotherapy. Patients were divided into 2 groups according to the length of SRI: <6 weeks (128 patients) versus >/=6 weeks (43 patients). The median follow-up period was 87 months (range, 22-167). RESULTS: The 8-year local control rates of patients with SRI <6 weeks and >/=6 weeks were 94.5% and 92.7%, respectively (P = 0.1140). When age, tumor size, resection margin status, combination with hormonal therapy, and SRI were incorporated into the Cox proportional hazards model, SRI <6 weeks and age at diagnosis >/=40 years were associated with increased local control (P = 0.0343 and 0.0264, respectively). In the subgroup analysis, SRI <6 weeks was correlated with a higher local control rate for patients aged <40 years (P = 0.0142). Among older patients, however, there was no statistical difference in local control according to SRI (P = 0.6655). Treatment interval had no impact on overall and distant metastasis-free survival. CONCLUSIONS: Early radiotherapy within 6 weeks of breast-conserving surgery is associated with increased local control in patients with node-negative breast cancer not undergoing chemotherapy.
机译：目的和背景：评价手术放疗间隔（SRI）对采用保乳手术和无化疗辅助放疗的淋巴结阴性乳腺癌患者局部控制的影响。方法：从1992年2月至2002年1月，对171例淋巴结阴性乳腺癌患者进行了保乳手术和无化学疗法的辅助放疗。整个乳房在28个部分中最高接受50.4 Gy的辐射，然后在肿瘤床上增强10 Gy。除放射治疗外，四十四名患者还接受了他莫昔芬治疗。根据SRI的长度将患者分为2组：<6周（128位患者）和> / = 6周（43位患者）。中位随访期为87个月（范围22-167）。结果：SRI <6周和> / = 6周的患者的8年局部控制率分别为94.5％和92.7％（P = 0.1140）。当将年龄，肿瘤大小，切除边缘状态，激素治疗和SRI纳入Cox比例风险模型时，SRI <6周和诊断年龄> / = 40岁与局部控制增加相关（P = 0.0343和分别为0.0264）。在亚组分析中，对于<40岁的患者，SRI <6周与较高的局部控制率相关（P = 0.0142）。然而，在老年患者中，根据SRI进行的局部控制无统计学差异（P = 0.6655）。治疗间隔对总体和远处无转移生存没有影响。结论：保乳手术后6周内的早期放疗与未接受化疗的淋巴结阴性乳腺癌患者的局部控制增加有关。

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