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首页> 外文期刊>Tumori. >An investigation into the combined effect of static magnetic fields and different anticancer drugs on K562 cell membranes.
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An investigation into the combined effect of static magnetic fields and different anticancer drugs on K562 cell membranes.

机译：研究静磁场和不同的抗癌药物对K562细胞膜的联合作用。

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AIMS AND BACKGROUND: Cell membranes were shown to be sensitive to and affected by static magnetic fields (SMF). METHODS: Cells were treated with four anticancer drugs followed by treatment with a combination of drugs and SMF. Individual cells were examined using atomic force microscopy (AFM). The drugs were taxol (alkaloid), doxorubicin (anthracycline), cisplatin (platinum compound) and cyclophosphamide (alkylating agent). RESULTS: Holes were observed in cells exposed to SMF but not in control groups. The number, size and shape of the holes were dependent on the drug type, SMF parameters and the duration of exposure. CONCLUSIONS: The results suggest that the application of a SMF could alter membrane permeability, increasing the flow of the anticancer drugs. This may be one of the reasons why SMF can strengthen the effect of anticancer drugs. Observations were also made of the effect of using different anticancer drugs. For example, the effect of SMF combined with taxol or cyclophosphamide on the cells was additive while the effect of SMF combined with cisplatin or doxorubicin was synergistic. The target sites of cisplatin and doxorubicin are nucleic acids; continued research is required into this important area to ascertain the effect of SMF on nucleic acids.
机译：目的和背景：显示细胞膜对静磁场（SMF）敏感并受其影响。方法：先用四种抗癌药治疗细胞，然后再用药物和SMF联合治疗。使用原子力显微镜（AFM）检查单个细胞。药物是紫杉醇（生物碱），阿霉素（蒽环类），顺铂（铂化合物）和环磷酰胺（烷基化剂）。结果：暴露于SMF的细胞中观察到孔，但对照组中未观察到孔。孔的数量，大小和形状取决于药物类型，SMF参数和暴露时间。结论：结果表明，SMF的应用可以改变膜的通透性，增加抗癌药物的流量。这可能是SMF可以增强抗癌药效果的原因之一。还观察了使用不同抗癌药的效果。例如，SMF与紫杉醇或环磷酰胺结合对细胞的作用是累加的，而SMF与顺铂或阿霉素结合的作用是协同的。顺铂和阿霉素的靶位是核酸。需要继续对该重要领域进行研究，以确定SMF对核酸的作用。

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