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首页> 外文期刊>Tumori. >Is complete axillary dissection necessary for all patients with positive findings on sentinel lymph node biopsy? Validation of a breast cancer nomogram for predicting the likelihood of a non-sentinel lymph node.
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Is complete axillary dissection necessary for all patients with positive findings on sentinel lymph node biopsy? Validation of a breast cancer nomogram for predicting the likelihood of a non-sentinel lymph node.

机译：对于所有前哨淋巴结活检阳性的患者，是否需要进行彻底的腋窝淋巴结清扫术？验证乳腺癌诺模图以预测非前哨淋巴结的可能性。

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AIM AND BACKGROUND: Axillary dissection in patients positive for sentinel lymph nodes is currently under discussion in the literature, since approximately only 50% of such patients has metastases in the remaining lymph nodes. To identify patients at risk for non-sentinel lymph nodes metastases, a nomogram was developed by the Breast Service of the Memorial Sloan-Kettering Cancer Center. The aim of this study was to assess the nomogram's predictive accuracy in a population of Italian breast cancer patients in our hospital. MATERIALS AND METHODS: The system of calculation used as variables prognostic factors of breast cancer: pathologic size, tumor type and nuclear grade, lymphovascular invasion, multifocality, estrogen receptor status, method of detection of the sentinel lymph nodes metastases (frozen section, serial hematoxylin-eosin, routine hematoxylin-eosin, and immunohistochemistry), number of positive and number of negative sentinel lymph nodes. RESULTS AND CONCLUSIONS: To measure the discrimination of the nomogram, a receiver-operating characteristic curve was construed, and the area under the curve was calculated. However, the area under the curve was 0.72, a very high value considering that the limit of acceptability is 0.70-0.80. The calculation system developed by the Memorial Sloan-Kettering Cancer Center provides a predictive value on the histopathologic state of sentinel lymph nodes.
机译：目的和背景：前哨淋巴结阳性的患者的腋窝淋巴结清扫术目前正在文献中进行讨论，因为大约只有50％的此类患者在其余淋巴结中有转移。为了确定存在非前哨淋巴结转移风险的患者，纪念斯隆-凯特琳癌症中心的乳房服务处制作了诺模图。这项研究的目的是评估在我院意大利乳腺癌患者人群中列线图的预测准确性。材料与方法：该计算系统用作乳腺癌的预后变量：病理学大小，肿瘤类型和核分级，淋巴管浸润，多灶性，雌激素受体状态，前哨淋巴结转移的检测方法（冷冻切片，系列苏木精） -伊红，常规苏木-伊红和免疫组化），前哨淋巴结阳性和阴性数。结果与结论：为了测量列线图的辨别力，构造了一个接收机工作特性曲线，并计算了曲线下的面积。但是，曲线下的面积为0.72，考虑到可接受极限为0.70-0.80，这是一个非常高的值。 Memorial Sloan-Kettering癌症中心开发的计算系统对前哨淋巴结的组织病理学状态具有预测价值。

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