NKT cells in immunoregulation of tumor immunity: a new immunoregulatory axis.

Terabe M; Berzofsky JA

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NKT cells in immunoregulation of tumor immunity: a new immunoregulatory axis.

机译：NKT细胞在肿瘤免疫免疫调节中的作用：一个新的免疫调节轴。

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CD1d-restricted natural killer T (NKT) cells have at least two subsets: type I, semi-invariant TCRalpha chain-expressing (Valpha14Jalpha18 in mice, Valpha24Jalpha18 in humans), and type II, variable TCRalpha chain-expressing. The protective role of NKT cells in tumor immunosurveillance and immunity has been well documented but paradoxically, there are also studies ascribing a suppressive role to these cells. Recent studies have resolved this paradox by revealing distinct roles for the two types of NKT cells, whereby type I NKT cells enhance anti-tumor responses and type II NKT cells suppress these responses. The finding of cross-regulation between the two types of NKT cells suggests a new immunoregulatory axis. Consideration of the cross-talk of NKT cells along with the well-defined suppression by regulatory T cells could provide new insights into cancer immunotherapy.

机译：限制CD1d的自然杀伤T细胞（NKT）具有至少两个子集：I型，半不变的TCRalpha链表达（小鼠中为Valpha14Jalpha18，人为Valpha24Jalpha18），以及II型，可变TCRalpha链表达。 NKT细胞在肿瘤免疫监测和免疫中的保护作用已得到充分证明，但自相矛盾的是，也有研究表明对这些细胞具有抑制作用。最近的研究通过揭示两种类型的NKT细胞的独特作用解决了这一悖论，即I型NKT细胞增强了抗肿瘤反应，而II型NKT细胞抑制了这些反应。两种类型的NKT细胞之间交叉调节的发现提示了新的免疫调节轴。考虑到NKT细胞的串扰以及调节性T细胞的明确抑制作用，可以为癌症免疫治疗提供新的见识。

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《Trends in immunology》 |2007年第11期|共6页
作者
Terabe M; Berzofsky JA;
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正文语种 eng
中图分类医学免疫学;
关键词
Neoplasms; Immunity; immunoregulation; Role; Psychological suppression; 肿瘤; 免疫性; 角色;

机译：Neoplasms;Immunity;immunoregulation;Role;Psychological suppression;肿瘤;免疫性;角色;

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专利

1. NKT cells in immunoregulation of tumor immunity: a new immunoregulatory axis. [J] . Terabe M, Berzofsky JA Trends in immunology . 2007,第11期

机译：NKT细胞在肿瘤免疫免疫调节中的作用：一个新的免疫调节轴。
2. NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis [J] . Jay A. Berzofsky, Masaki Terabe The journal of immunology . 2008,第6期

机译：NKT细胞在肿瘤免疫中：相对的子集定义一个新的免疫调节轴。
3. NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis [J] . Jay A. Berzofsky, Masaki Terabe The journal of immunology . 2008,第6期

机译：NKT细胞在肿瘤免疫中：相对的子集定义一个新的免疫调节轴。
4. Introduction of NKT cell, a novel immunoregulatory subset and in vitro studies involving activated NKT cell [C] . Huazhong Lu, Deming Sun, Feng Gao 11th Regional Western Pacific Congress of International Society of Blood Transfusion Nov, 2001 Shanghai . 2001

机译：NKT细胞（一种新的免疫调节子集）的引入以及涉及活化NKT细胞的体外研究
5. Immune evasion of CD1d molecules and NKT cells in the innate immune response against viruses. [D] . Cho, Sungyoo. 2005

机译：CD1d分子和NKT细胞在针对病毒的先天免疫应答中的免疫逃避。
6. Immunobiology: Type I NKT cells protect (and type II NKT cells suppress) the hosts innate antitumor immune response to a B-cell lymphoma [O] . Gourapura J. Renukaradhya, Masood A. Khan, Marcus Vieira, -1

机译：免疫生物学：I型NKT细胞保护（并抑制II型NKT细胞）宿主对B细胞淋巴瘤的先天性抗肿瘤免疫反应
7. Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma [O] . Renukaradhya, Gourapura J., Khan, Masood A., Vieira, Marcus, 2008

机译：I型NKT细胞可保护（并抑制II型NKT细胞）宿主对B细胞淋巴瘤的先天性抗肿瘤免疫反应

NKT cells in immunoregulation of tumor immunity: a new immunoregulatory axis.

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