• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in immunology >The regulatory power of glycans and their binding partners in immunity
【24h】

The regulatory power of glycans and their binding partners in immunity

机译：聚糖及其结合伴侣对免疫的调节作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Glycans and glycan-binding proteins are central to a properly functioning immune system. Perhaps the best known example of this is the selectin family of surface proteins that are primarily found on leukocytes, and which bind to endothelial glycans near sites of infection or inflammation and enable extravasation into tissues. In the past decade, however, several other immune pathways that are dependent on or sensitive to changes in glycan-mediated mechanisms have been revealed. These include antibody function, apoptosis, T helper (Th)1 versus Th2 skewing, T cell receptor signaling, and MHC class II antigen presentation. Here, we highlight how regulated changes in protein glycosylation both at the cell surface and on secreted glycoproteins can positively and negatively modulate the immune response.
机译：聚糖和聚糖结合蛋白对于正常运转的免疫系统至关重要。也许最著名的例子是表面蛋白的选择素家族，该蛋白主要存在于白细胞上，并与感染或炎症部位附近的内皮聚糖结合，并能渗入组织。然而，在过去的十年中，已经揭示了依赖于聚糖介导的机制的变化或对其敏感的其他几种免疫途径。这些包括抗体功能，细胞凋亡，T辅助（Th）1与Th2的偏斜，T细胞受体信号传导和MHC II类抗原呈递。在这里，我们强调在细胞表面和分泌的糖蛋白上蛋白质糖基化的调节变化如何能够正面和负面地调节免疫反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号