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首页> 外文期刊>Xenotransplantation >Method for perfusion decellularization of porcine whole liver and kidney for use as a scaffold for clinical-scale bioengineering engrafts
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Method for perfusion decellularization of porcine whole liver and kidney for use as a scaffold for clinical-scale bioengineering engrafts

机译:猪全肝和肾脏灌注脱细胞的方法,用作临床规模生物工程移植物的支架

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摘要

BackgroundWhole-organ engineering provides a new alternative source of donor organs for xenotransplantation. Utilization of decellularized whole-organ scaffolds, which can be created by detergent perfusion, is a strategy for tissue engineering. In this article, our aim is to scale up the decellularization process to human-sized liver and kidney to generate a decellularized matrix with optimal and stable characteristics on a clinically relevant scale.
机译:背景全器官工程为异种移植提供了新的供体器官替代来源。利用去细胞的全器官支架(可以通过去污剂灌注产生)是组织工程学的一种策略。在本文中,我们的目标是将脱细胞过程扩大到人体大小的肝脏和肾脏,以产生具有临床相关规模的最佳和稳定特性的脱细胞基质。

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