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首页> 外文期刊>Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides >Laboratory of Food Chemistry,Katholieke Universiteit Leuven,Kasteelpark Arenberg 20,B-3001 Leuven,Belgium
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Laboratory of Food Chemistry,Katholieke Universiteit Leuven,Kasteelpark Arenberg 20,B-3001 Leuven,Belgium

机译：鲁汶天主教大学食品化学实验室，比利时Kasteelpark Arenberg 20，B-3001比利时鲁汶

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Swelling behaviour is one of the important properties for microcapsules made by hydrogels,which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems.In this paper,alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively.With the volume swelling degree(5W)as an index,the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated.It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low 5_w.Considering the need of maintaining drug activity and drug loading,neutral pH and short gelation time were favorable.It was also noticed that S_w of internal gelation microcapsules was lower than that of external gelation microcapsules,which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser scanning microscope.
机译：溶胀行为是水凝胶制成的微胶囊的重要特性之一，当将微胶囊应用于药物输送系统时，它始终会影响药物的扩散和释放。本文通过不同的技术（称为外部或内部）制备了藻酸盐-壳聚糖微胶囊。以体积溶胀度（5W）为指标，研究了壳聚糖性能对两种微胶囊溶胀行为的影响，证明了低分子量和高浓度壳聚糖的微胶囊的产生。低5_w。考虑到需要维持药物活性和载药量，中性pH和较短的胶凝时间是有利的。还注意到内部凝胶微胶囊的S_w低于外部凝胶微胶囊的S_w，这是通过对结构的分析得出的。共聚焦激光扫描在内部或外部凝胶化海藻酸钙珠示波器。

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