• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Microbiology >A single microbial virulence factor induces diverse classes of host immune response
【24h】

A single microbial virulence factor induces diverse classes of host immune response

机译：单个微生物毒力因子可诱导多种类型的宿主免疫反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Host defense against microbial pathogens is mediated by both innate and adaptive immunity. In contrast to cells involved in the adaptive immune response, cells involved in the innate immune response primarily recognize microbial components as being of non-self origin through the cell-surface Toll-like receptors (TLRs). TLRs help to mount efficient antigen-specific adaptive immune responses by indirectly providing co-stimulatory signals to the interactions between professional antigen-presenting cells (dendritic cells; DCs) and T cells. These interactions lead to the differentiation of T helper (Th) cells into Th1 or Th2 cells, with distinct cytokine expression profiles. However, it is not known whether (and how) a single virulence factor from different pathogenic microorganisms induces a dissimilar pattern (i.e.Th1 or Th2) of adaptive immune responses in the host.
机译：宿主对微生物病原体的防御由先天免疫和适应性免疫介导。与参与适应性免疫反应的细胞相反，参与先天免疫反应的细胞主要通过细胞表面Toll样受体（TLR）识别微生物成分为非自身来源。 TLR通过向专业抗原呈递细胞（树突状细胞; DC）与T细胞之间的相互作用间接提供共刺激信号，帮助建立有效的抗原特异性适应性免疫应答。这些相互作用导致T辅助（Th）细胞分化为具有不同细胞因子表达特征的Th1或Th2细胞。然而，未知来自不同病原微生物的单一毒力因子是否（以及如何）在宿主中诱导不同的适应性免疫反应模式（即Th1或Th2）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号