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Candida biofilms and their role in infection

机译:念珠菌生物膜及其在感染中的作用

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Pathogenic fungi in the genus Candida can cause both superficial and serious systemic disease, and are now recognized as major agents of hospital-acquired infection. Many Candida infections involve the formation of biofilms on implanted devices such as indwelling catheters or prosthetic heart valves. Biofilms of Candida albicans formed in vitro on catheter material consist of matrix-enclosed microcolonies of yeasts and hyphae, arranged in a bilayer structure. The biofilms are resistant to a range of antifungal agents currently in clinical use, including amphotericin B and fluconazole, and there appear to be multiple resistance mechanisms. Recent studies with mixed biofilms containing Candida and bacterial species suggest that extensive and striking interactions occur between the prokaryotic and eukaryotic cells in these adherent populations.
机译:念珠菌属的致病真菌可引起浅表性和严重的全身性疾病,现已被公认为医院获得性感染的主要病原体。许多念珠菌感染涉及在植入装置(例如留置导管或人工心脏瓣膜)上形成生物膜。体外在导管材料上形成的白色念珠菌生物膜由酵母和菌丝的基质包围的微菌落组成,排列成双层结构。该生物膜对目前临床上使用的多种抗真菌剂具有抗性,包括两性霉素B和氟康唑,并且似乎存在多种抗性机制。最近对含有念珠菌和细菌物种的混合生物膜的研究表明,在这些贴壁种群中,原核和真核细胞之间发生了广泛而惊人的相互作用。

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