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The building blocks of pathogenicity

机译:致病性的基础

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As the workhorse of bacterial molecular genetics, the publication of any new Escherichia coli genome sequence is always greeted with great interest. Welch et al. [1] have provided us with the complete sequence of another E. coli genotype, namely the uropathogenic E. coli (UPEC) strain CFT073. The previously sequenced genomes were that of the relatively benign laboratory strain K12 [2], and two independent publications of enterohaemorrhagic E. coli (EHEC) 0157:H7 strains EDL933 and Sakai [3,4]. UPEC are a diverse group of extraintestinal pathogens, able to live harmlessly as commensals within the gut as well as being able to colonize a variety of other niches within the human body including the perineum, bladder, urethra and kidneys.
机译:作为细菌分子遗传学的主力军,任何新的大肠杆菌基因组序列的出版总是引起人们极大的兴趣。 Welch等。 [1]为我们提供了另一种大肠杆菌基因型的完整序列,即泌尿致病性大肠杆菌(UPEC)菌株CFT073。先前测序的基因组是相对良性的实验室菌株K12的基因组[2],以及肠出血性大肠杆菌(EHEC)0157:H7菌株EDL933和Sakai的两个独立出版物[3,4]。 UPEC是多种肠外病原体,它们可以作为肠道内无害的生活,也可以在人体内包括会阴部,膀胱,尿道和肾脏的许多其他壁colon中定殖。

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