Insertion of the bacterial type III translocon: not your average needle stick

Coombes BK; Finlay BB

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Insertion of the bacterial type III translocon: not your average needle stick

机译：插入细菌III型转座子：不是您的平均针刺

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Bacterial type III secretion systems are thought to translocate virulence proteins directly from the bacterial cytoplasm into host cells through a continuous molecular channel. Little is known about how the apparatus itself interacts with membranes and whether insertion of this structure into the host membrane has consequences for the bacteria apart from its beneficial role in delivering virulence proteins. New evidence suggests that membrane insertion of the bacterial type III apparatus might turn on a calcium-dependent signaling pathway resulting in phagolysosomal fusion.

机译：据认为，III型细菌分泌系统可通过连续分子通道将毒力蛋白直接从细菌细胞质转移到宿主细胞中。除了设备本身如何与膜相互作用以及将这种结构插入宿主膜是否会对细菌产生影响外，人们对其知之甚少，除了它在传递毒力蛋白方面的有益作用。新证据表明，细菌III型装置的膜插入可能会开启钙依赖性信号传导途径，导致吞噬体融合。

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来源
《Trends in Microbiology》 |2005年第3期|共4页
作者
Coombes BK; Finlay BB;
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正文语种 eng
中图分类微生物学;
关键词
Bacterial Proteins metabolism physiology; Calcium metabolism physiology; Cell Membrane metabolism physiology; Exocytosis physiology; Gram-Negative Bacteria pathogenicity physiology; Gram-Negative Bacterial Infections microbiology; Lysosomes physiology; Research Support; Non-U.S. Gov't; Virulence Factors metabolism physiology;

机译：细菌蛋白质代谢生理学;钙代谢生理学;细胞膜代谢生理学;胞吐作用生理学;革兰氏阴性细菌致病性生理学;革兰氏阴性细菌感染微生物学;溶酶体生理学;研究支持;美国以外的其他地区。毒力因子代谢生理;

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1. Insertion of the bacterial type III translocon: not your average needle stick [J] . Coombes BK, Finlay BB Trends in Microbiology . 2005,第3期

机译：插入细菌III型转座子：不是您的平均针刺
2. Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells. [J] . Hayward RD, Cain RJ, McGhie EJ, Molecular Microbiology . 2005,第3期

机译：细菌III型转座子与胆固醇的结合对于将毒性效应物传递到哺乳动物细胞中至关重要。
3. Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach [J] . Zilkenat Susann, Franz-Wachtel Mirita, Stierhof York-Dieter, Molecular & cellular proteomics: MCP . 2016,第5期

机译：结合定量蛋白质组学方法确定完整的III型细菌分泌针复合物的化学计量
4. Development of a two DOF needle driver for CT-guided needle insertion-type interventional robotic system [C] . Ki Young Kim, Hyun Soo Woo, Jang Ho Cho, IEEE International Symposium on Robot and Human Interactive Communication . 2017

机译：用于CT引导式针头插入式介入机器人系统的两自由度针头驱动器的开发
5. NMR studies of bacterial type III secretion apparatus needle and tip proteins and the NMR structure of the hantavirus nucleocapsid coiled-coil domain. [D] . Wang, Yu. 2009

机译：细菌III型分泌设备的针尖蛋白质的NMR研究以及汉坦病毒核衣壳卷曲螺旋结构域的NMR结构。
6. The type III secretion system needle tip and translocon [O] . Supratim Dey, Amritangshu Chakravarty, Pallavi Guha Biswas, 2019

机译：III型分泌系统针尖端和转运
7. The type III secretion system needle, tip, and translocon [O] . Supratim Dey, Amritangshu Chakravarty, Pallavi Guha Biswas, 2019

机译：III型分泌系统针，尖端和转运

Insertion of the bacterial type III translocon: not your average needle stick

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