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Independent evolution of competence regulatory cascades in streptococci?

机译:链球菌能力调节级联反应的独立进化?

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Natural genetic transformation is a mechanism of horizontal gene transfer that is widely distributed in bacteria and requires assembly of a DMA uptake machinery. Transformable bacteria use fundamentally the same machine, which in most species is assembled only in cells that are developing competence. Competence regulation usually differs between unrelated species. Here, we examine whether related streptococci use the same competence regulatory cascade. Phylogenetic analyses of streptococcal genome sequences reveal the existence of two paralogous two-component regulatory systems, either of which might control competence. This suggests the distribution of streptococci into two groups that use competence regulatory cascades that have at least partly evolved independently. Comparison of data obtained with two transformable streptococci, Streptococcus pneumonias and Streptococcus mutans, provides support to this suggestion.
机译:自然遗传转化是水平基因转移的一种机制,广泛地分布在细菌中,需要组装DMA摄取机制。可转化细菌基本上使用同一台机器,在大多数物种中,这种机器仅在正在发育的细胞中组装。无关物种之间的能力调节通常不同。在这里,我们检查相关的链球菌是否使用相同的能力调节级联。链球菌基因组序列的系统发育分析表明,存在两个旁系的两组分调节系统,其中任何一个都可以控制能力。这表明链球菌可分为使用至少部分独立进化的能力调节级联的两组。比较两种可转化的链球菌,肺炎链球菌和变形链球菌获得的数据,为这一建议提供了支持。

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