The capsular dynamics of Cryptococcus neoformans

Diane McFadden; Oscar Zaragoza; Arturo Casadevall

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The capsular dynamics of Cryptococcus neoformans

机译：新型隐球菌的荚膜动力学

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Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in immunocompromised individuals and latently infects many healthy individuals. C. neoformans, unlike other human pathogenic fungi, is surrounded by a polysaccharide capsule that is essential for survival and enables C. neoformans to thwart the mammalian immune system. The capsule is a dynamic structure that undergoes changes in size and rearranges during budding. Here, the latest information and unresolved questions regarding capsule synthesis, structure, assembly, growth and rearrangements are discussed along with the concept that self-assembly is important in capsular dynamics.

机译：新型隐球菌（Cryptococcus neoformans）是一种土壤真菌，可在免疫功能低下的个体中引起威胁生命的疾病，并潜在感染许多健康个体。与其他人类致病性真菌不同，新孢子虫被多糖胶囊包围，该多糖胶囊对于生存至关重要，并使新孢子虫能够阻止哺乳动物的免疫系统。胶囊是一种动态结构，在出芽期间会发生大小变化和重新排列。在这里，讨论了有关胶囊合成，结构，组装，生长和重排的最新信息和未解决的问题，以及自组装在胶囊动力学中很重要的概念。

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《Trends in Microbiology》 |2006年第11期|共9页
作者
Diane McFadden; Oscar Zaragoza; Arturo Casadevall;
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1. The capsular dynamics of Cryptococcus neoformans [J] . Diane McFadden, Oscar Zaragoza, Arturo Casadevall Trends in Microbiology . 2006,第11期

机译：新型隐球菌的荚膜动力学
2. A synthetic glycan array containing Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide fragments allows the mapping of protective epitopes [J] . Lorenzo Guazzelli, Conor J. Crawford, Rebecca Ulc, Chemical science . 2020,第34期

机译：含有含有海豚葡萄糖葡萄糖氧基毒瘤荚膜多糖片段的合成甘油阵列允许绘图保护性表位
3. Reduced phagocytosis and killing of Cryptococcus neoformans biofilm-derived cells by J774.16 macrophages is associated with fungal capsular production and surface modification [J] . Lee Hiu Ham, Del Pozzo Jaclyn, Salamanca Sergio A., Fungal Genetics and Biology . 2019,第1期

机译：通过J774.16巨噬细胞降低吞噬细胞症和杀死隐性球菌新族裔生物膜衍生细胞的细胞与真菌荚膜生产和表面改性有关
4. Cryptococcus neoformans capsule protects cell from oxygen reactive species generated by antimicrobial photodynamic inactivation [C] . Renato Araujo Prates, Michael R. Hamblin, Ilka T. Kato, Mechanisms for low-light therapy VI . 2011

机译：新型隐球菌胶囊保护细胞免受抗菌素光动力失活产生的氧反应性物种的伤害
5. Binding and internalization of glucuronoxylomannan, the major capsular polysaccharide of Cryptococcus neoformans, by murine peritoneal macrophages. [D] . Chang, Zong-Liang. 2009

机译：鼠腹膜巨噬细胞对葡糖醛酸氧甘露聚糖（新隐球菌的主要荚膜多糖）的结合和内在化。
6. Cryptococcus neoformans Capsular GXM Conformation and Epitope Presentation: A Molecular Modelling Study [O] . Michelle M. Kuttel, Arturo Casadevall, Stefan Oscarson 2020

机译：新型隐球菌荚膜GXM构象和抗原决定簇呈递：分子建模研究。
7. Detection of Cryptococcus neoformans capsular polysaccharide antigen in asymptomatic HIV-infected patients Detección del antígeno capsular del Cryptococcus neoformans en pacientes asintomáticos infectados por HIV [O] . R. Negroni, C. Cendoya, A.I. Arechavala, 1995

机译：无症状HIV感染患者中新型隐球菌荚膜抗原的检测HIV感染无症状患者中新型隐球菌荚膜抗原的检测

The capsular dynamics of Cryptococcus neoformans

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