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Roundtrip explorations of bacterial infection: from single cells to the entire host and back

机译:细菌感染的往返探索:从单个细胞到整个宿主再到整个宿主

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Host–pathogen interactions are highly regulated, dynamic processes that take place at the molecular, cellular and organ level. Innovative imaging technologies have emerged recently to investigate the underlying mechanisms of host–pathogen interactions. Innovations in fluorescence microscopy enable functional studies on the single-cell level. New light microscopes have been developed that improve the resolution to less than 100 nm. At the other extreme, intravital microscopy enables the correlation of cellular events on the organ level. This is also achieved by alternatives to microscopy such as bioluminescence, positron-emission tomography and magnetic resonance imaging. The methodologies described here will have a tremendous effect on our understanding of host–pathogen interactions.
机译:宿主与病原体的相互作用是高度调控的动态过程,发生在分子,细胞和器官水平。最近出现了创新的成像技术来研究宿主与病原体相互作用的潜在机制。荧光显微镜的创新使得可以在单细胞水平上进行功能研究。已经开发了将分辨率提高到小于100 nm的新型光学显微镜。在另一个极端,活体显微镜检查可以在器官水平上关联细胞事件。这也可以通过替代显微镜来实现,例如生物发光,正电子发射断层扫描和磁共振成像。这里描述的方法将对我们对宿主-病原体相互作用的理解产生巨大影响。

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