Using or abusing: viruses and the cellular DNA damage response

Caroline E. Lilley; Rachel A. Schwartz; Matthew D. Weitzman

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Using or abusing: viruses and the cellular DNA damage response

机译：使用或滥用：病毒和细胞DNA损伤反应

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During infection, viruses attempt to hijack the cell while the host responds with various defense systems. Traditional defenses include the interferon response and apoptosis, but recent work suggests that this antiviral arsenal also includes the cellular DNA damage response machinery. The observation of interactions between viruses and cellular DNA repair proteins has not only uncovered new complexities of the virus–host interaction but is also reinforcing the view that viruses can reveal key regulators of cellular pathways through the proteins they target.

机译：在感染过程中，病毒试图劫持细胞，而宿主会以各种防御系统做出响应。传统的防御手段包括干扰素反应和细胞凋亡，但是最近的研究表明，这种抗病毒药库还包括细胞DNA损伤反应机制。病毒与细胞DNA修复蛋白之间相互作用的观察不仅揭示了病毒与宿主相互作用的新复杂性，而且还强化了这样的观点，即病毒可以通过它们靶向的蛋白揭示细胞途径的关键调节因子。

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《Trends in Microbiology》 |2007年第3期|共8页
作者
Caroline E. Lilley; Rachel A. Schwartz; Matthew D. Weitzman;
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1. Using or abusing: viruses and the cellular DNA damage response [J] . Caroline E. Lilley, Rachel A. Schwartz, Matthew D. Weitzman Trends in Microbiology . 2007,第3期

机译：使用或滥用：病毒和细胞DNA损伤反应
2. Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response [J] . Carter Rachel J., Nickson Catherine M., Thompson James M., International Journal of Radiation Oncology, Biology, Physics . 2018,第3期

机译：高线性能量转移α-颗粒和质子诱导的复杂DNA损伤触发特定的细胞DNA损伤反应
3. Deciphering MET-dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomics reveals Ser1016 as a novel MET phosphosite that regulates cellular response to irradiation. [J] . Intelligence: A Multidisciplinary Journal . 2020,第期

机译：通过定量磷蛋白质的DNA损伤对全局细胞反应的全局细胞反应进行依赖性调节揭示SER1016作为调节对辐照细胞反应的新型磷酸盐。
4. QUANTITATIVE SPATIAL PROTEOMICS ANALYSIS OF THE CELLULAR DNA DAMAGE RESPONSE USING 10-PLEX TMT, 4-PLEX ITRAQ AND 8-PLEX ITRAQ ISOBARIC TAGS [C] . Sylvie Bourassa, Benjamin Nehme, Jean-Philippe Gagne, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用10-Plex TMT，4-PLEX ITRAQ和8-PLEX ITRAQ ITRAQ iSobaric标签使用10-PLEX TMT的细胞DNA损伤响应的定量空间蛋白质组学分析
5. DNA repair systems and cellular responses to DNA damage. [D] . Hinz, John Michael. 2001

机译：DNA修复系统和细胞对DNA损伤的反应。
6. Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response [O] . Fengxiang Wei, Peng Hao, Xiangzhong Zhang, 2018

机译：依托泊苷诱导的DNA损伤不仅影响DNA损伤反应还影响多种细胞途径
7. The interplay between MYCN and the DNA damage response: modulation of MYCN expression, its interactions with components of the DNA damage response and cellular responses to N-myc following genotoxic stress [O] . Duarte Alexandra 2012

机译：mYCN与DNa损伤反应之间的相互作用：mYCN表达的调节，与DNa损伤反应成分的相互作用以及基因毒性应激后对N-myc的细胞反应

Using or abusing: viruses and the cellular DNA damage response

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