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Finding novel metabolic genes through plant-prokaryote phylogenomics

机译:通过植物原核生物系统组学发现新的代谢基因

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Plants and prokaryotes share thousands of genes. Those with known functions mostly encode enzymes of primary metabolism or other key biochemical components, and the same is almost surely true of those whose function is still obscure. The availability of hundreds of sequenced genomes and of rich postgenomic resources now makes possible the use of comparative genomics ('phylogenomics') of plants and prokaryotes to infer, and then verify, functions for such unknown genes. In this type of analysis, plant and prokaryote data each inform the search for function, and do so synergistically. This breaks with the past pattern of gene discovery, in which the information flow was most often unidirectional from prokaryotes to plants.
机译:植物和原核生物共享数千个基因。具有已知功能的酶大部分编码初级代谢酶或其他关键生化成分的酶,对于那些功能仍不清楚的酶几乎可以肯定。数百种测序基因组和丰富的后基因组资源的可用性现在使得利用植物和原核生物的比较基因组学(“系统基因组学”)来推断然后验证此类未知基因的功能成为可能。在这种类型的分析中,植物和原核生物数据各自为功能搜索提供信息,并协同进行。这与过去的基因发现模式不符,后者的信息流通常是从原核生物到植物的单向信息。

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