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首页> 外文期刊>Trends in Microbiology >The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more.
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The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more.

机译：沙门氏菌PmrAB调节剂：脂多糖修饰，抗菌肽耐药性等。

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摘要

Microbes are able to sense and respond to their environment primarily through the use of two-component regulatory systems. Many of these systems activate virulence-factor expression and are regulated by host-derived signals, having evolved to control gene expression at the key time and place for optimal establishment and maintenance of infection. Salmonella spp. are enteric pathogens that are able to survive both within host macrophages during systemic spread and killing by innate immune factors at intestinal mucosal surfaces. This review focuses on a key mechanism of pathogenesis that involves the PmrA-PmrB two-component system, which is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments.
机译：微生物能够主要通过使用两组分监管系统来感知和响应其环境。这些系统中的许多系统激活毒力因子表达并受到宿主来源信号的调控，这些系统已在关键时间和地点进化为控制基因表达，以实现最佳的感染建立和维持。沙门氏菌肠病原体既可以在宿主巨噬细胞内全身扩散期间生存，又可以被肠道粘膜表面的先天免疫因子杀死。这篇综述集中在涉及PmrA-PmrB两组分系统的致病关键机制上，该系统通过直接或间接的方式在体内被激活，并调节修饰脂多糖的基因，从而有助于宿主（和非宿主）环境中的生存。

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