HIV-1 attachment: another look.

Ugolini S; Sattentau QJ; Mondor I

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HIV-1 attachment: another look.

机译：HIV-1附件：另一种外观。

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HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virion and the cell surface could dominate the attachment process.

机译：通常认为HIV-1与宿主细胞的附着是通过CD4和gp120之间的高亲和力结合发生的。但是，与病毒体相关的gp120与细胞CD4的结合通常很弱，并且大多数允许HIV-1感染的细胞类型很少表达CD4。因此，病毒体和细胞表面之间的其他相互作用可能会主导附着过程。

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《Trends in Microbiology》 |1999年第4期|共6页
作者
Ugolini S; Sattentau QJ; Mondor I;
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正文语种 eng
中图分类微生物学;
关键词
Antigens; CD4: Metabolism; Cell Adhesion Molecules: Metabolism; Heparan Sulfate Proteoglycan: Metabolism; Human; HIV Envelope Protein gp120: Metabolism; HIV Infections: Virology; HIV-1: Metabolism; HIV-1: Pathogenicity; Receptors; Cell Surface: Metabolism; Receptors; CCR5: Metabolism; Receptors; CXCR4: Metabolism;

机译：抗原;CD4：新陈代谢;细胞粘附分子：新陈代谢;硫酸乙酰肝素蛋白聚糖：新陈代谢;人类;HIV信封蛋白gp120：新陈代谢;HIV感染：病毒学;HIV-1：新陈代谢;HIV-1：致病性;受体;细胞表面：新陈代谢;受体;CCR5：代谢;受体;CXCR4：代谢;

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专利

1. HIV-1 attachment: another look. [J] . Ugolini S, Sattentau QJ, Mondor I Trends in Microbiology . 1999,第4期

机译：HIV-1附件：另一种外观。
2. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1 H -pyrrolo[2,3- c]pyridin-3-yl)-2-oxoethanone (BMS-488043) [J] . Kadow J.F., Ueda Y., Meanwell N.A., Journal of Medicinal Chemistry . 2012,第5期

机译：人类1型免疫缺陷病毒（HIV-1）附着的抑制剂6. BMS-663749的临床前和人类药代动力学分析，BMS-663749是HIV-1附着抑制剂2-（4-苯甲酰基-1-哌嗪基）-1-（ 4,7-二甲氧基-1 H-吡咯并[2,3- c]吡啶-3-基）-2-氧杂蒽酮（BMS-488043）
3. Activity of the HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068, against CD4-independent viruses and HIV-1 envelopes resistant to other entry inhibitors [J] . LiZ., ZhouN., SunY., Antimicrobial agents and chemotherapy. . 2013,第9期

机译：HIV-1附着抑制剂BMS-626529（前药BMS-663068的活性成分）对不依赖CD4的病毒和对其他进入抑制剂具有抵抗力的HIV-1包膜的活性
4. 'I’m Scared to Look. But I’m Dying to Know': Information Seeking and Sharing on Pro-Ana Weblogs [C] . Rachel A. Fleming-May, Laura E. Miller Proceedings of the 73rd ASISamp;T annual meeting: navigating streams in an information ecosystems . 2010

机译：“我不敢看。但是我渴望知道”：Pro-Ana Weblogs上的信息查找和共享
5. Mechanisms of attachment of HIV-1 to CD4 positive and negative cells and the role in virus infectivity. [D] . Olinger, Gene Garrard, Jr. 2001

机译：HIV-1与CD4阳性和阴性细胞的附着机制及其在病毒感染性中的作用。
6. Scaffold attachment factor B suppresses HIV-1 infection of CD4+ T cells by preventing binding of RNA polymerase II to HIV-1s long terminal repeat [O] . Li Ma, Li Sun, Xia Jin, 2018

机译：支架附着因子B通过阻止RNA聚合酶II与HIV-1的长末端重复序列的结合来抑制CD4 + T细胞的HIV-1感染
7. Activity of the HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068, against CD4-Independent Viruses and HIV-1 Envelopes Resistant to Other Entry Inhibitors [O] . Zhufang Li, Nannan Zhou, Yongnian Sun, 2013

机译：HIV-1附着抑制剂BMS-626529的活性，前药BMS-663068的活性成分，对抗CD4独立的病毒和HIV-1耐用于其他进入抑制剂的包膜

HIV-1 attachment: another look.

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