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首页> 外文期刊>Trends in Microbiology >The role of porins in neisserial pathogenesis and immunity
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The role of porins in neisserial pathogenesis and immunity

机译：孔蛋白在奈瑟菌发病机理和免疫中的作用

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摘要

Neisseria meningitidis and Neisseria gonorrhoeae are Gram-negative pathogenic bacteria responsible for bacterial meningitis and septicemia, and the sexually transmitted disease gonorrhea, respectively. Porins are the most represented outer membrane proteins in the pathogenic Neisseria species, functioning as pores for the exchange of ions, and are characterized by a trimeric β-barrel structure. Neisserial porins have been shown to act as adjuvants in the immune response via activation of B cells and other antigen-presenting cells (APCs). Their effect on the immune response is mediated by upregulation of the costimulatory molecule B7-2 (CD86) on the surface of APCs, an effect that is Toll-like receptor 2- and MyD88-dependent. The effect of neisserial porins on the immune system also involves interaction with components of the complement cascade. Furthermore, neisserial porins co-localize with mitochondria of target cells, where they appear to modulate apoptosis.
机译：脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌分别是引起细菌性脑膜炎和败血病以及性病淋病的革兰氏阴性致病菌。孔蛋白是致病性奈瑟氏球菌中最典型的外膜蛋白，起离子交换孔的作用，并以三聚体β桶结构为特征。奈瑟氏菌孔蛋白已显示出通过激活B细胞和其他抗原呈递细胞（APC）发挥免疫佐剂的作用。它们对免疫反应的作用是由APC表面上的共刺激分子B7-2（CD86）上调介导的，这种作用是Toll样受体2和MyD88依赖性的。奈瑟氏菌孔蛋白对免疫系统的作用还涉及与补体级联成分的相互作用。此外，奈瑟氏菌孔蛋白与靶细胞的线粒体共定位，它们似乎在调节细胞凋亡。

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