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What we can learn about Escherichia coli through application of Gene Ontology

机译:通过应用基因本体论我们可以了解到大肠杆菌

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How we classify the genes, products and complexes that are present or absent in genomes, transcriptomes, proteomes and other datasets helps us place biological objects into subsystems with common functions, see how molecular functions are used to implement biological processes and compare the biology of different species and strains. Gene Ontology (GO) is one of the most successful systems for classifying biological function. Although GO is widely used for eukaryotic genomics, it has not yet been widely used for bacterial systems. The potential applications of GO are currently limited by the need to improve the annotation of bacterial genomes with GO and to improve how prokaryotic biology is represented in the ontology. Here, we discuss why GO should be adopted by microbiologists, and describe recent efforts to build and maintain high-quality GO annotation for Escherichia coli as a model system.
机译:我们如何对基因组,转录组,蛋白质组和其他数据集中存在或不存在的基因,产物和复合物进行分类,有助于我们将生物物体放入具有共同功能的子系统中,了解如何使用分子功能来实现生物过程并比较不同生物学的生物学种类和品系。基因本体论(GO)是对生物学功能进行分类的最成功的系统之一。尽管GO广泛用于真核基因组学,但尚未广泛用于细菌系统。目前,GO的潜在应用受到限制,需要通过GO改进细菌基因组的注释,并改进原核生物学在本体中的表示方式。在这里,我们讨论了微生物学家为什么应采用GO,并描述了最近为构建和维持高质量的大肠杆菌注释模型模型所做的努力。

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