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LPxTG surface proteins of enterococci

机译:肠球菌的LPxTG表面蛋白

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Enterococci have become an important cause of nosocomial infections since the late 1980s. Several surface proteins have been implicated in contributing to infections caused by Enterococcus faecalis and Enterococcus faecium. Understanding the in vivo function of enterococcal surface proteins, particularly their role in directing interactions with the host during infection, is essential to explain the success of enterococci as nosocomial pathogens. Here we review current knowledge of enterococcal LPxTG surface proteins, including aggregation substance, enterococcal surface protein, three collagen-binding microbial surface components that recognize adhesive matrix molecules (Ace, Acm, Scm) and pili (Ebp, PilA and PilB), their interactions with host molecules and their role in pathogenicity and biofilm development.
机译:自1980年代后期以来,肠球菌已成为医院感染的重要原因。几种表面蛋白与导致粪肠球菌和粪肠球菌引起的感染有关。了解肠球菌表面蛋白的体内功能,尤其是它们在感染过程中与宿主相互作用的直接作用,对于解释肠球菌作为医院病原体的成功至关重要。在这里,我们回顾一下肠球菌LPxTG表面蛋白的当前知识,包括聚集物质,肠球菌表面蛋白,三种识别胶原基质分子(Ace,Acm,Scm)和菌毛(Ebp,PilA和PilB)的胶原结合微生物表面成分,以及它们之间的相互作用宿主分子及其在致病性和生物膜发育中的作用。

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