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首页> 外文期刊>Trends in Microbiology >What is type VI secretion doing in all those bugs?
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What is type VI secretion doing in all those bugs?

机译：在所有这些错误中，VI型分泌物在做什么？

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The identification of bacterial secretion systems capable of translocating substrates into eukaryotic cells via needle like appendages has opened fruitful and exciting areas of microbial pathogenesis research The recent discovery of the type VI secretion system (T6SS) was met with early speculation that It too acts as a 'needle' that pathogens aim at host cells New reports demonstrate that certain T6SSs are potent mediators of inter-bacterial interactions In light of these findings, we examined earlier data indicating its role in pathogenesis We conclude that although T6S can, in rare instances, directly influence interactions with higher organisms, the broader physiological significance of the system is likely to provide defense against simple eukaryotic cells and other bacteria in the environment The crucial role of T6S in bacterial interactions, along with its presence in many organisms relevant to disease, suggests that it might be a key determinant in the progression and outcome of certain human polymicrobial infections
机译：能够通过针状附属物将底物转移到真核细胞中的细菌分泌系统的鉴定为微生物发病机理研究开辟了富有成果和令人兴奋的领域。最近发现VI型分泌系统（T6SS）的最新发现是它也可以作为细菌。病原体针对宿主细胞的“针”新报告表明某些T6SS是细菌间相互作用的有效介体鉴于这些发现，我们检查了表明其在发病机理中作用的早期数据。我们得出结论，尽管在极少数情况下T6S可以直接影响T6S与高等生物的相互作用时，该系统的更广泛的生理意义很可能为环境中的简单真核细胞和其他细菌提供防御。T6S在细菌相互作用中的关键作用以及它在与疾病相关的许多生物中的存在表明它可能是进展和结果的关键决定因素f某些人类微生物感染

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