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首页> 外文期刊>Trends in Microbiology >Mycobacterium abscessus: a new player in the mycobacterial field
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Mycobacterium abscessus: a new player in the mycobacterial field

机译：脓肿分枝杆菌：分枝杆菌领域的新成员

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摘要

Mycobacterium abscessus, a relative of Koch's bacillus (the bacterium that causes tuberculosis), has recently emerged as the cause of an increasing number of both community- and hospital-acquired infections in humans; it also constitutes a serious threat for cystic fibrosis patients. This situation is worsened by its exceptionally high natural and acquired antibiotic resistance that complicates treatment. Although a rapid grower, it shares some traits with Koch's bacillus, including the ability to induce a persistent lung disease associated with caseous lesions, a landmark of Mycobacterium tuberculosis infection. Its genome sequence and microarrays are now available, and efficient genetic tools have recently been developed. Here we consider the various advantages of using this species as an experimental model to study tuberculosis and other related mycobacterial diseases.
机译：脓肿分枝杆菌是科赫氏杆菌（引起结核的细菌）的近亲，最近已成为导致社区和医院获得性感染人数增加的原因。它也对囊性纤维化患者构成严重威胁。这种情况因其异常高的天然和获得性抗生素耐药性而恶化，使治疗复杂化。尽管生长迅速，但它与科赫芽孢杆菌有一些共同特征，包括诱发与干酪样病灶相关的持续性肺部疾病的能力，这是结核分枝杆菌感染的标志。现在可以得到其基因组序列和微阵列，并且最近已经开发了有效的遗传工具。在这里，我们考虑使用该物种作为实验模型来研究结核病和其他相关分枝杆菌疾病的各种优势。

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