Polyhistidine triad proteins of pathogenic streptococci

Plumptre Charles D.; Ogunniyi Abiodun D.; Paton James C.

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Polyhistidine triad proteins of pathogenic streptococci

机译：致病性链球菌的多组氨酸三联体蛋白

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The polyhistidine triad (Pht) proteins are an intriguing family of proteins found on the surface of members of the genus Streptococcus. Their defining feature is the presence of multiple copies of the eponymous His triad motif HxxHxH. This review focuses on the Pht proteins of Streptococcus pneumoniae, which contribute to virulence and are leading candidates for inclusion in protein-based pneumococcal vaccines. They appear to have multiple functions, including metal ion homeostasis, evasion of complement deposition and adherence of bacteria to host cells. Across the streptococci, there are many Pht homologs, which can be grouped according to structural features. Critically, there is considerable potential to use members of the Pht protein family as components of vaccines targeted at other streptococci.

机译：聚组氨酸三联体（Pht）蛋白是链球菌属成员表面上一个有趣的蛋白家族。它们的定义特征是存在多个同名的His triad基序HxxHxH。这篇综述的重点是肺炎链球菌的Pht蛋白，这种蛋白会增加毒性，并且是包含在基于蛋白的肺炎球菌疫苗中的主要候选药物。它们似乎具有多种功能，包括金属离子稳态，逃避补体沉积以及细菌与宿主细胞的粘附。在整个链球菌中，有许多Pht同源物，可以根据结构特征进行分组。至关重要的是，使用Pht蛋白家族的成员作为针对其他链球菌的疫苗的组件具有很大的潜力。

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《Trends in Microbiology》 |2012年第10期|共9页
作者
Plumptre Charles D.; Ogunniyi Abiodun D.; Paton James C.;
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正文语种 eng
中图分类微生物学;
关键词
polyhistidine triad protein; zinc homeostasis; factor H binding; complement evasion; cellular adherence; streptococcal vaccines;

机译：多组氨酸三联体蛋白;锌稳态;因子H结合;补体逃逸;细胞粘附;链球菌疫苗;

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1. Polyhistidine triad proteins of pathogenic streptococci [J] . Plumptre Charles D., Ogunniyi Abiodun D., Paton James C. Trends in Microbiology . 2012,第10期

机译：致病性链球菌的多组氨酸三联体蛋白
2. Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae Streptococcus pneumoniae [J] . Luo Zhenyao, Pederick Victoria G., Paton James C., FEBS letters. . 2018,第13期

机译：来自链球菌肺炎链球菌肺炎链球菌肺炎链球菌的HT3基序的结构表征
3. Molecular and biological characterization of histidine triad protein in group A streptococci [J] . Kunitomo E, Terao Y, Okamoto S, Microbes and infection . 2008,第4期

机译：A组链球菌中组氨酸三联体蛋白的分子生物学特性
4. Antagonistic activity of Enterococcus faecium L3 against different groups of pathogenic streptococci [C] . E. Yermolenko, A. Chernish, G. Aleshina, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：肠球菌粪便拮抗性活性L3对不同致病性链球菌的不同组
5. Transfer of pathogenic and non-pathogenic cytosolic proteins between motor neurons in vivo in chimeric mice. [D] . Thomas, Eleanor Varian. 2017

机译：在嵌合小鼠体内，运动神经元之间的病原性和非病原性胞质蛋白的转移。
6. Vaccination against Streptococcus pneumoniae Using Truncated Derivatives of Polyhistidine Triad Protein D [O] . Charles D. Plumptre, Abiodun D. Ogunniyi, James C. Paton -1

机译：使用多组氨酸三联体蛋白D的截短衍生物对肺炎链球菌进行疫苗接种
7. Vaccination against Streptococcus pneumoniae using truncated derivatives of polyhistidine triad protein D. [O] . Charles D Plumptre, Abiodun D Ogunniyi, James C Paton 2013

机译：使用多组氨酸三联体蛋白D的截短衍生物对肺炎链球菌进行疫苗接种
8. Cell Surface Proteins of Animal Group C Streptococci Mediating Binding of PlasmaProteins [R] . Jonsson, H. 1994

机译：动物群C链球菌的细胞表面蛋白介导血浆蛋白的结合

Polyhistidine triad proteins of pathogenic streptococci

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