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首页> 外文期刊>Trends in Microbiology >Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways
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Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways

机译：涉及抗泛素途径的早期抗病毒应答的病毒逃逸机制

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Early innate and cell-intrinsic responses are essential to protect host cells against pathogens. In turn, viruses have developed sophisticated mechanisms to establish productive infections by counteracting host innate immune responses. Increasing evidence indicates that these antiviral factors may have a dual role by directly inhibiting viral replication as well as by sensing and transmitting signals to induce antiviral cytokines. Recent studies have pointed at new, unappreciated mechanisms of viral evasion of host innate protective responses including manipulating the host ubiquitin (Ub) system. Virus-mediated inhibition of antiviral factors by Ub-dependent degradation is emerging as a crucial mechanism for evading the antiviral response. In addition, recent studies have uncovered new mechanisms by which virus-encoded proteins inhibit Ub and Ub-like (Ubl) modification of host proteins involved in innate immune signaling pathways. Here we discuss recent findings and novel strategies that viruses have developed to counteract these early innate antiviral defenses.
机译：早期的先天性和细胞内源性反应对于保护宿主细胞免于病原体至关重要。反过来，病毒已经开发出复杂的机制来通过抵消宿主先天免疫反应来建立生产性感染。越来越多的证据表明，这些抗病毒因子可能通过直接抑制病毒复制以及通过感应和传递信号来诱导抗病毒细胞因子发挥双重作用。最近的研究指出了新的，未知的病毒逃逸宿主先天性保护性反应的机制，包括操纵宿主遍在蛋白（Ub）系统。病毒介导的Ub依赖性降解对抗病毒因子的抑制作用正在成为逃避抗病毒反应的关键机制。此外，最近的研究发现了新的机制，通过这种机制，病毒编码的蛋白质可抑制涉及先天免疫信号传导途径的宿主蛋白质的Ub和Ub样（Ubl）修饰。在这里，我们讨论了病毒已经发展起来以抵消这些早期先天性抗病毒防御的最新发现和新策略。

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