HIV Gag polyprotein: processing and early viral particle assembly

Bell Neil M.; Lever Andrew M. L.

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HIV Gag polyprotein: processing and early viral particle assembly

机译：HIV Gag多蛋白：加工和早期病毒颗粒组装

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Over the past several decades, extensive research into the Gag polyprotein, the main structural protein of HIV-1 and all other retroviruses, has changed the way that we describe Gag's role within viral lifecycles. Initially thought of as a simple scaffold protein forming the viral core, Gag has demonstrated the ability to specifically recognize genomic RNA and both viral and host proteins as it traffics to the cell membrane. There, Gag forms higher ordered structures required for the correct assembly, budding, and maturation of new infectious particles.

机译：在过去的几十年中，对Gag多蛋白（HIV-1和所有其他逆转录病毒的主要结构蛋白）的广泛研究，改变了我们描述Gag在病毒生命周期中的作用的方式。最初被认为是形成病毒核心的简单支架蛋白，Gag证明了在运输到细胞膜时能够特异性识别基因组RNA以及病毒和宿主蛋白的能力。在那里，Gag形成了更高层次的结构，这些结构是新的传染性粒子正确组装，萌芽和成熟所需的。

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《Trends in Microbiology》 |2013年第3期|共9页
作者
Bell Neil M.; Lever Andrew M. L.;
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原文格式 PDF
正文语种 eng
中图分类微生物学;
关键词
HIV-1; Gag; viral assembly; viral maturation; RNA packaging;

机译：HIV-1;Gag;病毒装配;病毒成熟;RNA包装;

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专利

1. HIV Gag polyprotein: processing and early viral particle assembly [J] . Bell Neil M., Lever Andrew M. L. Trends in Microbiology . 2013,第3期

机译：HIV Gag多蛋白：加工和早期病毒颗粒组装
2. Context Surrounding Processing Sites Is Crucial in Determining Cleavage Rate of a Subset of Processing Sites in HIV-1 Gag and Gag-Pro-Pol Polyprotein Precursors by Viral Protease [J] . Sook-Kyung Lee, Marc Potempa, Madhavi Kolli, The Journal of biological chemistry . 2012,第16期

机译：背景加工位点对于通过病毒蛋白酶确定HIV-1 GAG和GAG-Pro-Pol Poldentors的加工位点的裂解率至关重要
3. Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles [J] . Nolwenn Jouvenet, Sanford M. Simon, Paul D. Bieniasz Proceedings of the National Academy of Sciences of the United States of America . 2009,第45期

机译：成像单个病毒颗粒组装过程中HIV-1基因组与Gag的相互作用
4. pH Modulation of Myristate Exposure in the Matrix Domain of HIV-1 Gag Polyprotein: A Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) Study [C] . Ioannis Karageorgos, Kerry Bauer, Jeffrey W. Hudgens ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：HIV-1 GAG Polyprotein基质结构蛋白在Matrix结构域的pH调节：氢氘交换质谱（HDX-MS）研究
5. CCL2 Mobilizes ALIX from Actin Cytoskeleton to Enhance Gag Trafficking and HIV Virion Release-Effect of Gag polymorphism on HIV-1 Viral Fitness [D] . Ajasin, David Olanrewaju. 2019

机译：CCL2从肌动蛋白的细胞骨架调动Alix，以增强GAG多态性对HIV-1病毒健身的GAG贩运和艾滋病毒病毒虫释放效应
6. Context Surrounding Processing Sites Is Crucial in Determining Cleavage Rate of a Subset of Processing Sites in HIV-1 Gag and Gag-Pro-Pol Polyprotein Precursors by Viral Protease [O] . Sook-Kyung Lee, Marc Potempa, Madhavi Kolli, 2012

机译：上下文周围的加工位点是决定病毒蛋白酶中HIV-1 Gag和Gag-Pro-Pol多蛋白前体中加工位点亚型的裂解率的关键
7. Context surrounding processing sites is crucial in determining cleavage rate of a subset of processing sites in HIV-1 Gag and Gag-Pro-Pol polyprotein precursors by viral protease [O] . Lee, Sook-Kyung, Potempa, Marc, Kolli, Madhavi, 2012

机译：围绕加工位点的背景对于通过病毒蛋白酶确定HIV-1 Gag和Gag-pro-pol多蛋白前体中一部分加工位点的切割速率至关重要
8. Incorporation of 12-Methoxydodecanoate into the Human Immunodeficiency Virus 1Gag Polyprotein Precursor Inhibits Its Proteolytic Processing and Virus Production in a Chronically Infected Human Lymphoid Cell Line [R] . Bryant, M. L., Ratner, L., Duronio, R. J., 1991

机译：将12-甲氧基十二烷酸酯掺入人免疫缺陷病毒1Gag多蛋白前体中抑制其在慢性感染的人淋巴细胞系中的蛋白水解加工和病毒产生

HIV Gag polyprotein: processing and early viral particle assembly

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