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首页> 外文期刊>Trends in Microbiology >Quorum sensing inhibitors: how strong is the evidence?
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Quorum sensing inhibitors: how strong is the evidence?

机译：仲裁感应抑制剂：证据有多强？

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摘要

Because of its promising effect as an alternative to antibiotics, quorum sensing disruption is an intensively studied field, and there are many studies that describe the quorum sensing inhibitory activity of natural and synthetic compounds. In this opinion article, we present an overview of recent literature with respect to quorum sensing inhibitors. Most of this research is based on experiments with quorum sensing signal molecule reporter strains. However, these experiments are prone to bias due to other effects compounds may have on reporter strains. We argue that researchers should perform adequate control experiments and should carefully assess toxicity of the compounds in the bacterial species they are working with in order to confirm that what they observe really is quorum sensing inhibition.
机译：由于其替代抗生素的前景看好，因此群体感应破坏是一个深入研究的领域，并且有许多研究描述了天然和合成化合物的群体感应抑制活性。在这篇观点文章中，我们介绍了有关群体感应抑制剂的最新文献综述。这项研究大部分是基于群体感应信号分子报告基因菌株的实验。但是，由于化合物可能会对报告菌株产生其他影响，因此这些实验容易产生偏差。我们认为研究人员应进行适当的对照实验，并应仔细评估所研究细菌中化合物的毒性，以确认他们观察到的确实是群体感应抑制。

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