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首页> 外文期刊>Trends in Microbiology >Biofilm switch and immune response determinants at early stages of infection
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Biofilm switch and immune response determinants at early stages of infection

机译：感染早期的生物膜转换和免疫反应决定因素

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Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a sessile lifestyle and start producing a biofilm matrix. The initial steps of in vivo biofilm development are poorly characterized and difficult to assess experimentally. A great amount of in vitro evidence has shown that accumulation of high levels of cyclic dinucleotides (c-di-NMPs) is the most prevalent hallmark governing the initiation of biofilm development by bacteria. As mentioned above, recent studies also link detection of c-di-NMPs by host cells with the activation of a type I interferon immune response against bacterial infections. We discuss here c-di-NMP signaling and the host immune response in the context of the initial steps of in vivo biofilm development.RI Toledo-Arana, Alejandro/F-9624-2011OI Toledo-Arana, Alejandro/0000-0001-8148-6281
机译：生物膜发育被认为是大多数慢性细菌感染的主要毒力因子。建立生物膜群落后，在组织周围生长的浮游细胞转变为无柄的生活方式，并开始产生生物膜基质。体内生物膜发展的初始步骤表征不充分，并且难以通过实验进行评估。大量体外证据表明，高水平的环状二核苷酸（c-di-NMPs）积累是控制细菌启动生物膜发展的最普遍特征。如上所述，最近的研究还将宿主细胞对c-di-NMP的检测与针对细菌感染的I型干扰素免疫应答的激活联系在一起。我们在这里讨论体内生物膜发展的初始步骤中的c-di-NMP信号传导和宿主免疫反应.RI Toledo-Arana，Alejandro / F-9624-2011OI Toledo-Arana，Alejandro / 0000-0001-8148 -6281

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