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Solving the etiology of dental caries

机译:解决龋齿的病因

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For decades, the sugar-fermenting, acidogenic species Streptococcus mutans has been considered the main causative agent of dental caries and most diagnostic and therapeutic strategies have been targeted toward this microorganism. However, recent DNA- and RNA-based studies from carious lesions have uncovered an extraordinarily diverse ecosystem where S. mutans accounts only a tiny fraction of the bacterial community. This supports the concept that consortia formed by multiple microorganisms act collectively, probably synergistically, to initiate and expand the cavity. Thus, antimicrobial therapies are not expected to be effective in the treatment of caries and other polymicrobial diseases that do not follow classical Koch's postulates.
机译:数十年来,糖发酵,产酸物种变形链球菌一直被认为是龋齿的主要病原体,并且大多数诊断和治疗策略都针对这种微生物。但是,最近来自龋齿病变的基于DNA和RNA的研究发现了异常多样的生态系统,其中变形链球菌仅占细菌群落的一小部分。这支持了由多种微生物形成的聚生体共同起作用(可能协同作用)以引发和扩大空腔的概念。因此,预期抗微生物疗法不能有效地治疗不遵循经典科赫氏假设的龋齿和其他多微生物疾病。

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