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Revisiting phage therapy: new applications for old resources

机译:再次研究噬菌体疗法:旧资源的新应用

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The success of phage therapy is dependent on the development of strategies able to overcome the limitations of bacteriophages as therapeutic agents, the creation of an adequate regulatory framework, the implementation of safety protocols, and acceptance by the general public. Many approaches have been proposed to circumvent phages' intrinsic limitations but none have proved to be completely satisfactory. In this review we present the major hurdles of phage therapy and the solutions proposed to circumvent them. A thorough discussion of the advantages and drawbacks of these solutions is provided and special attention is given to the genetic modification of phages as an achievable strategy to shape bacteriophages to exhibit desirable biological properties.
机译:噬菌体疗法的成功取决于能否克服作为治疗剂的噬菌体局限性的策略,建立适当的监管框架,实施安全规程以及是否为公众所接受。已经提出了许多方法来规避噬菌体的固有限制,但是没有一种方法被证明是完全令人满意的。在这篇综述中,我们介绍了噬菌体治疗的主要障碍以及为避免它们而提出的解决方案。提供了对这些解决方案的优缺点的透彻讨论,并特别注意了对噬菌体的遗传修饰,以作为使噬菌体成形以表现出所需生物学特性的可实现策略。

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