• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Microbiology >Intracellular vs extracellular recognition of pathogens-common concepts in mammals and flies
【24h】

Intracellular vs extracellular recognition of pathogens-common concepts in mammals and flies

机译：病原体的细胞内和细胞外识别-哺乳动物和果蝇中的常见概念

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There are common themes in innate immune defense systems across the animal and plant kingdoms. Pathogen recognition is commonly based on the identification of microbial molecular patterns by defined receptors and the subsequent activation of signaling pathways that initiate a defense response to fend off the invading microorganism. The existence of mammalian Toll-like receptors (TLRs) and the recent identification of two mammalian nucleotidebinding site leucine-rich repeat (NBS-LRR) proteins (NOD1 and NOD2) as intracellular sensors of bacterial products bring new insights into the possibility of extracellular versus intracellular pathogen recognition and signal transduction depending on the nature of the infection. The homology between TLRs and the Toll system in Drosophila suggests that conserved defense mechanisms are likely to be shared by diverse organisms.
机译：在动植物界的先天免疫防御系统中有共同的主题。病原体识别通常基于对已定义受体的微生物分子模式的识别以及信号通路的后续激活，从而启动防御反应以抵御入侵的微生物。哺乳动物Toll样受体（TLR）的存在以及最近鉴定出的两个哺乳动物核苷酸结合位点富含亮氨酸的重复序列（NBS-LRR）蛋白（NOD1和NOD2）作为细菌产物的细胞内传感器带来了新的洞察力，可进一步了解细胞外抗细胞内病原体识别和信号转导取决于感染的性质。 TLR和果蝇Toll系统之间的同源性表明，保守的防御机制很可能由多种生物体共享。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号