A star with stripes: zebrafish as an infection model

Astrid M. van der Sar; Ben J. Appelmelk; Christina M. J. E. Vandenbroucke-Grauls; Wilbert Bitter

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A star with stripes: zebrafish as an infection model

机译：有条纹的星星：斑马鱼作为感染模型

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The zebrafish, one of the favourite animals of developmental biologists, is rapidly gaining ground in infection models. Various experimental infection models have been set up to study both human and fish pathogens in more detail. The most interesting of these pathogens is perhaps Mycobacterium marinum, a close relative of Mycobacterium tuberculosis, and causes fish tuberculosis. With the zebrafish, genetic screens in a vertebrate host with a fully developed immune system are possible. In addition, bacterial infections can be analysed in real-time in zebrafish embryos. Here, we discuss the use of the zebrafish as a host for studying infectious diseases, and also the challenges, benefits and hurdles associated with using this model.

机译：斑马鱼是发育生物学家最喜欢的动物之一，正在感染模型中迅速普及。已经建立了各种实验性感染模型以更详细地研究人和鱼的病原体。这些病原体中最有趣的可能是结核分枝杆菌的近亲海洋分枝杆菌，它引起了鱼的结核病。使用斑马鱼，可以在具有完全发达的免疫系统的脊椎动物宿主中进行基因筛选。另外，可以实时分析斑马鱼胚胎中的细菌感染。在这里，我们讨论了斑马鱼作为宿主研究传染病的方法，以及与使用该模型相关的挑战，收益和障碍。

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《Trends in Microbiology》 |2004年第10期|共7页
作者
Astrid M. van der Sar; Ben J. Appelmelk; Christina M. J. E. Vandenbroucke-Grauls; Wilbert Bitter;
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正文语种 eng
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1. A star with stripes: zebrafish as an infection model [J] . Astrid M. van der Sar, Ben J. Appelmelk, Christina M. J. E. Vandenbroucke-Grauls, Trends in Microbiology . 2004,第10期

机译：有条纹的星星：斑马鱼作为感染模型
2. transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival [J] . Christiane Nüsslein-Volhard, Brigitte Walderich, Hans Georg Frohnh?fer, Biology Open . 2013,第9期

机译：透明，影响斑马鱼条纹形成的基因，编码虹膜线虫生存所需的线粒体蛋白Mpv17透明，一种影响斑马鱼条纹形成的基因，编码虹膜线虫生存透明所需的线粒体蛋白Mpv17，透明，影响斑马鱼条纹形成的基因斑马鱼，编码虹膜虹膜生存所需的线粒体蛋白Mpv17
3. transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival [J] . Christiane Nüsslein-Volhard, Brigitte Walderich, Hans Georg Frohnh?fer, Biology Open . 2013,第7期

机译：透明，影响斑马鱼条纹形成的基因，编码虹膜线虫生存所需的线粒体蛋白Mpv17透明，一种影响斑马鱼条纹形成的基因，编码虹膜线虫生存透明所需的线粒体蛋白Mpv17，透明，影响斑马鱼条纹形成的基因斑马鱼，编码虹膜虹膜生存所需的线粒体蛋白Mpv17
4. Essential Proteins and Functional Modules in the Host-Pathogen Interactions from Innate to Adaptive Immunity C. albicans-zebrafish Infection Model [C] . Chia-Chou Wu, Bor-Sen Chen International Conference on Bioinformatics Models, Methods and Algorithms . 2015

机译：基因蛋白质和功能模块在宿主病原体中与先天素与自适应免疫的相互作用C. albicans-Zebrafish感染模型
5. A study of how letters to the editor published in "The Stars and Stripes" newspaper between March 1, 1918, and November 15, 1918, reflected the morale of the troops during World War I. [D] . Hatch, Vicky Ann. 2009

机译：关于1918年3月1日至1918年11月15日之间在《星条旗报》上发表给编辑的信的研究反映了第一次世界大战期间部队的士气。
6. Modelling stripe formation in zebrafish: an agent-based approach [O] . Alexandria Volkening, Björn Sandstede 2015

机译：斑马鱼中条纹形成的建模：基于代理的方法
7. Logistic regression models to predict stripe rust infections on wheat and yield response to foliar fungicide application on wheat in Kansas [O] . Eddy Rachel 100

机译：Logistic回归模型预测小麦条锈病感染和对堪萨斯小麦叶面杀菌剂施用的产量反应
8. Stars or Stripes: A Comparative Study of Finite and Transfinite Techniques forSurface Modelling [R] . van Overveld, C. W. A. M., Verhoeven, M. 1994

机译：星条纹：表面建模的有限和超限技术的比较研究

A star with stripes: zebrafish as an infection model

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