• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Microbiology >Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions
【24h】

Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions

机译：细菌纤维素的生物合成：操纵子，亚基，产物和功能的多样性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies of bacterial cellulose biosynthesis, including structural characterization of a functional cellulose synthase complex, provided the first mechanistic insight into this fascinating process. In most studied bacteria, just two subunits, BcsA and BcsB, are necessary and sufficient for the formation of the polysaccharide chain in vitro. Other subunits - which differ among various taxa - affect the enzymatic activity and product yield in vivo by modulating (i) the expression of the biosynthesis apparatus, (ii) the export of the nascent beta-D-glucan polymer to the cell surface, and (iii) the organization of cellulose fibers into a higher-order structure. These auxiliary subunits play key roles in determining the quantity and structure of resulting biofilms, which is particularly important for the interactions of bacteria with higher organisms - leading to rhizosphere colonization and modulating the virulence of cellulose-producing bacterial pathogens inside and outside of host cells. We review the organization of four principal types of cellulose synthase operon found in various bacterial genomes, identify additional bcs genes that encode components of the cellulose biosynthesis and secretion machinery, and propose a unified nomenclature for these genes and subunits. We also discuss the role of cellulose as a key component of biofilms and in the choice between acute infection and persistence in the host.
机译：细菌纤维素生物合成的最新研究，包括功能性纤维素合酶复合物的结构表征，为这一令人着迷的过程提供了第一个机理见解。在大多数研究的细菌中，只有两个亚基BcsA和BcsB对于在体外形成多糖链是必要和充分的。通过调节（i）生物合成装置的表达，（ii）新生的β-D-葡聚糖聚合物向细胞表面的输出，以及在其他生物分类之间不同的其他亚基，会影响体内的酶活性和产物产量。 （iii）将纤维素纤维组织成高阶结构。这些辅助亚基在确定所得生物膜的数量和结构中起关键作用，这对于细菌与高级生物的相互作用特别重要-导致根际定植并调节宿主细胞内外的产纤维素细菌病原体的毒力。我们审查了在各种细菌基因组中发现的四种主要类型的纤维素合酶操纵子的组织，确定了编码纤维素生物合成和分泌机制成分的其他bcs基因，并提出了这些基因和亚基的统一命名法。我们还讨论了纤维素作为生物膜关键成分的作用以及急性感染和宿主持久性之间的选择。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号