Bordetella pertussis adenylate cyclase: a toxin with multiple talents

Daniel Ladant; Agnes Ullmann

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Bordetella pertussis adenylate cyclase: a toxin with multiple talents

机译：百日咳博德特氏菌腺苷酸环化酶：一种多才多艺的毒素

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Bordetella pertussis secretes a calmodulinactivated adenylate cyclase toxin (CyaA) that is able to deliver its amino-terminal catalytic domain into the cytosol of eukaryotic cells. The novelty of the structural organization and conformational flexibility of the CyaA catalytic domain has opened up the way for exploiting this protein as a tool for several biological applications, including epitope delivery, protein targeting and characterization of protein-protein interactions.

机译：百日咳博德特氏菌分泌一种钙调蛋白活化的腺苷酸环化酶毒素（CyaA），该毒素能够将其氨基末端催化结构域传递到真核细胞的细胞质中。 CyaA催化结构域的结构组织和构象灵活性的新颖性为利用这种蛋白质作为几种生物学应用（包括表位递送，蛋白质靶向和蛋白质-蛋白质相互作用的表征）的工具开辟了道路。

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来源
《Trends in Microbiology》 |1999年第4期|共5页
作者
Daniel Ladant; Agnes Ullmann;
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原文格式 PDF
正文语种 eng
中图分类微生物学;
关键词
Bordetella pertussis; multiple talents; adenylate cyclase; structure-function relationships; eukaryotic cells;

机译：百日咳博德特氏菌;多才多艺;腺苷酸环化酶;结构-功能关系;真核细胞;

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1. Bordetella pertussis adenylate cyclase: a toxin with multiple talents [J] . Daniel Ladant, Agnes Ullmann Trends in Microbiology . 1999,第4期

机译：百日咳博德特氏菌腺苷酸环化酶：一种多才多艺的毒素
2. Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools [J] . Nicholas H Carbonetti Future Microbiology . 2010,第3期

机译：百日咳毒素和腺苷酸环化酶毒素：百日咳博德特氏菌的关键毒力因子和细胞生物学工具
3. Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools. [J] . Carbonetti NH Future microbiology . 2010,第3期

机译：百日咳毒素和腺苷酸环化酶毒素：百日咳博德特氏菌的关键毒力因子和细胞生物学工具。
4. ENGINEERING THE ADENYLATE CYCLASE TOXIN FOR USE AS A BORDETELLA PERTUSSIS VACCINE ANTIGEN [C] . Andrea M. DiVenere Biochemical and molecular engineering XX: the next generation of biochemical engineering: from nanoscale to industrial scale . 2017

机译：工程化腺苷酸环化酶毒素，用作百日咳百日咳疫苗抗原
5. Construction, mucosal immunogenicity and in vitro protective efficacy of a genetically engineered pertussis toxin-cholera toxin chimeric protein against Bordetella pertussis. [D] . Salloum, Danny F. 2001

机译：基因工程百日咳毒素-霍乱毒素嵌合蛋白针对百日咳博德特氏菌的构建，粘膜免疫原性和体外保护功效。
6. Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin. [O] . V M Gordon, S H Leppla, E L Hewlett 1988

机译：受体介导的内吞作用抑制剂可阻止炭疽芽孢杆菌腺苷酸环化酶毒素的进入但百日咳博德特氏菌腺苷酸环化酶毒素的阻止则不会。
7. Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin [O] . V M Gordon, S H Leppla, E L Hewlett 1988

机译：受体介导的内吞作用的抑制剂阻断芽孢杆菌腺苷酸环盐的进入，但不是波尔德菌氨基酸酯环氨基酶毒素的
8. FRET-Based Method for Probing the Conformational Behavior of an Intrinsically Disordered Repeat Domain from Bordetella pertussis Adenylate Cyclase [R] . Szilvay, G. R., Blenner, M. A., Shur, O., 2009

机译：基于FRET的方法探讨百日咳博德特氏菌腺苷酸环化酶本征无序重复域的构象行为

Bordetella pertussis adenylate cyclase: a toxin with multiple talents

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