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Viral replication and the coactivators p300 and CBP

机译:病毒复制与共激活因子p300和CBP

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Productive viral infection requires coordinate regulation of viral and cellular gene expression. Viruses of different classes have evolved different mechanisms to conform to, adapt to and exploit programs of cellular gene expression. Many viral gene products influence and respond to cellular signals that control differentiation and proliferation Transcriptional coactivators are central to the regulation of the expression of genes controlling these events. p300 and CBP are closely related coactivators that regulate the transcription of specific genes, modify chromatin structure and influence cell cycle progression. In this review, the different molecular interactions of proteins encoded by DNA tumor viruses and lentiviruses with these transcriptional coactivators and related cellular proteins are summarized.
机译:生产性病毒感染需要协调调节病毒和细胞基因的表达。不同类别的病毒已经进化出不同的机制来顺应,适应和利用细胞基因表达程序。许多病毒基因产物影响并响应控制分化和增殖的细胞信号。转录共激活因子对于调节控制这些事件的基因的表达至关重要。 p300和CBP是密切相关的共激活因子,可调节特定基因的转录,修饰染色质结构并影响细胞周期进程。在这篇综述中,总结了DNA肿瘤病毒和慢病毒编码的蛋白质与这些转录共激活因子和相关细胞蛋白质的不同分子相互作用。

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