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Ureaplasma urealyticum: an opportunity for combinatorial genomics

机译:解脲脲原体:组合基因组学的机会

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Examination of genomic or enzymatic activity data alone neither provides a complete picture of metabolic function or potential nor confidently reveals sites amenable to inhibition. Furthermore, in some cases, gene annotation and in aqua assays disagree by describing gene annotation without enzyme activity and enzyme activity without homologous annotation. The newly sequenced genome of Ureaplasma urealyticum (parvum) is another prokaryote example of the class Mollicutes where such confounding differences are observed. The little-considered role of some proteins as multifunctional enzymes-substitutes for 'missing' genes - could both partially explain the apparent anomalies and relate to any inaccurate deductions of inhibitor function. A combinatorial analysis involving available evidence of genomic sequence, transcription, translational phenomena, structure and enzymatic activity gives the best picture of the organism's vital metabolic alternatives.
机译:仅检查基因组或酶活性数据既不能提供完整的代谢功能或潜力图,也不能自信地揭示出易于抑制的位点。此外,在某些情况下,基因注释和水分析中的描述存在差异,即描述了没有酶活性的基因注释和没有同源注释的酶活性。新测序的解脲脲原体(parvum)的基因组是Mollicutes类的另一个原核生物实例,其中观察到了这种混杂的差异。一些蛋白质作为多功能酶替代“缺失”基因的作用很少考虑,既可以部分解释明显的异常现象,又与抑制剂功能的任何不正确推论有关。组合分析涉及可利用的基因组序列,转录,翻译现象,结构和酶活性的证据,从而可以最好地了解生物体重要的代谢替代物。

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