Genetic manipulation of spirochetes - light at the end of the tunnel

Felipe C. Cabello; Marina L. Sartakova; Elena Yu. Dobrikova

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Genetic manipulation of spirochetes - light at the end of the tunnel

机译：螺旋体的遗传操作-隧道尽头的光

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Spirochetes cause many important diseases in humans and animals, including syphilis, relapsing fever, leptospirosis and Lyme disease. Recent advances in molecular genetics have allowed Koch's molecular postulates to be applied to the study of the virulence factors in these bacteria. Such advances include the use of electroporation, the identification of several antibiotic resistance phenotypes as useful genetic markers, the development of extrachromosomal cloning vectors and the isolation of knockout mutants and their complementation.

机译：螺旋体会导致人类和动物许多重要的疾病，包括梅毒，复发性发热，钩端螺旋体病和莱姆病。分子遗传学的最新进展已使科赫的分子假说可用于研究这些细菌中的毒力因子。这些进展包括电穿孔的应用，几种抗生素抗性表型的鉴定作为有用的遗传标记，染色体外克隆载体的开发以及敲除突变体及其互补的分离。

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《Trends in Microbiology》 |2001年第6期|共4页
作者
Felipe C. Cabello; Marina L. Sartakova; Elena Yu. Dobrikova;
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正文语种 eng
中图分类微生物学;
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1. Genetic manipulation of spirochetes - light at the end of the tunnel [J] . Felipe C. Cabello, Marina L. Sartakova, Elena Yu. Dobrikova Trends in Microbiology . 2001,第6期

机译：螺旋体的遗传操作-隧道尽头的光
2. Genetic characterization of the human relapsing fever spirochete Borrelia miyamotoi in vectors and animal reservoirs of Lyme disease spirochetes in France [J] . Jean-Fran?ois Cosson, Lorraine Michelet, Julien Chotte, Parasites Vectors . 2014,第4期

机译：人类复发发烧的遗传表征螺旋体Borrelia Miyamotoi在法国莱姆病螺旋中的血丝病
3. Symbiotic spirochetes in the termite hindgut: phylogenetic identification of ectosymbiotic spirochetes of oxymonad protists [J] . Iida T., Ohtoko K., Kudo T., FEMS Microbiology Ecology . 2000,第1期

机译：白蚁后肠中的共生螺旋体：羟单胞菌原生生物的外生共生螺旋体的系统发育鉴定
4. GENETICAL AND SEROLOGICAL CHARACTERIZATION OF JAPANESE CANINE INTESTINAL SPIROCHETES [C] . N Prapasarakul, N Monmal, C Tasu, Congress of the International Pig Veterinary Society . 2002

机译：日本犬肠螺旋化学的遗传和血清学特征
5. Comparative population genetics of Lyme disease spirochete (Borrelia burgdorferi) and its tick vector (Ixodes scapularis) in the United States. [D] . Qiu, Wei-Gang. 1999

机译：在美国，莱姆病螺旋体（Borrelia burgdorferi）及其壁虱载体（Ixodes scapularis）的比较种群遗传学。
6. Development of a Modified Gentamicin Resistance Cassette for Genetic Manipulation of the Oral Spirochete Treponema denticola [O] . Jiang Bian, J. Christopher Fenno, Chunhao Li 2012

机译：改良的庆大霉素抗性盒的开发用于遗传操作口腔螺旋体密螺旋体
7. Genetic Manipulation of the Relapsing Fever Spirochete Borrelia hermsii Permits Novel Investigation into the Role of Factor H Binding in Borrelial Virulence [O] . Fine Lindy 2011

机译：复发性发烧螺旋体伯氏疏螺旋体的遗传操纵允许对H因子在硼酸致病性中的作用进行新的研究
8. Positive Stain for Light and Electron Microscopic Demonstration of Spirochetes in Subgingival Plaque and Crevicular Fluid Samples from Periodontal Diseased Sites. (Reannouncement with New Availability Information). [R] . Giammara, B., Burkes, E. J., Scruggs, R., 1989

机译：牙周病患者龈下菌斑和龈沟液中螺旋体光和电镜观察的阳性染色。（重新公布新的可用性信息）。

Genetic manipulation of spirochetes - light at the end of the tunnel

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