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LaSota vaccination may not protect against the lesions of velogenic newcastle disease in chickens

机译：LaSota疫苗可能无法预防鸡新城疫致病

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Two groups of six weeks old cockerels comprising 40 immunized and 40 non-immunized birds were inoculated intramuscularly with VGF-1, which is a local Nigerian strain of velogenic Newcastle disease virus (VNDV). Immunized birds did not show any clinical signs except significant loss (p < 0.05) in body weight on days 5 and 20 post inoculation (PI). But the non-immunized birds showed clinical signs of disease characterized by anorexia and drowsiness from day 2 PI. These were followed on day 3 PI by depression, diarrhoea, opisthotonus, weight loss (p < 0.05) and high mortalities (96.9%). Both the immunized and non-immunized groups showed severe atrophy of the bursa, spleen and thymus. Histopathological section of these lymphoid organs showed necrosis and depletion of lymphocytes. Both the gross and microscopic lesions were more severe in the non-immunized birds. Marked ballooning degeneration was observed in the bursal follicles of the non-immunized birds. This lesion has not been described earlier for any other disease and could be diagnostic for VND. Our results also showed that VND can cause marked atrophy of the lymphoid organs, which may lead to immunosupression without the characteristic signs of Newcastle disease (ND) in vaccinated chickens. This no doubt emphasizes the limitation of vaccination as a biosecurity measure in poultry industry.
机译：对两组六周大的公鸡（包括40只经免疫和40只未免疫的家禽）进行肌肉内接种VGF-1，VGF-1是尼日利亚当地的新城疫病毒（VNDV）株。免疫禽只在接种后第5天和第20天体重显着下降（p <0.05），但未显示任何临床体征。但是，未免疫的禽类在感染后第2天就表现出以厌食和嗜睡为特征的疾病临床症状。在感染后第3天出现抑郁，腹泻，羊水过多，体重减轻（p <0.05）和高死亡率（96.9％）。免疫组和未免疫组均显示滑囊，脾脏和胸腺严重萎缩。这些淋巴器官的组织病理学切片显示出坏死和淋巴细胞耗竭。在未免疫的禽类中，肉眼和显微镜下的病变都更为严重。在未免疫的鸟类的囊泡中观察到明显的气球膨胀变性。该病灶尚未在其他任何疾病中进行过描述，可以诊断为VND。我们的研究结果还表明，VND可以引起淋巴器官明显萎缩，这可能导致免疫抑制而没有接种鸡的新城疫（ND）的特征性体征。这无疑强调了疫苗接种作为家禽业生物安全措施的局限性。

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