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首页> 外文期刊>Tropical Animal Health and Production >La Sota vaccination may not protect against virus shedding and the lesions of velogenic Newcastle disease in commercial turkeys
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La Sota vaccination may not protect against virus shedding and the lesions of velogenic Newcastle disease in commercial turkeys

机译：LA SOTA疫苗接种可能无法防止病毒脱落和商业火鸡的泌尿动态新城疫病变

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The aim of this project is to study the clinical signs and lesion of velogenic Newcastle disease (vND) in commercial turkeys, and also to find out if La Sota vaccination offered protection against these signs and lesions. The cockerels were included as positive controls. One hundred and twenty turkey poults and cockerels were divided into eight groups as follows: unvaccinated unchallenged turkeys (UUT), unvaccinated challenged turkeys (UCT), vaccinated unchallenged turkeys (VUT), vaccinated challenged turkeys (VCT), and along the same lines, the cockerel groups were UUC, UCC, VUC and vaccinated challenged cockerels (VCC). Vaccination was at 3 weeks of age while challenge was at 6 weeks of age. The unvaccinated turkeys and cockerels (UCT and UCC) showed different degrees of depression, diarrhoea and later paralysis at challenge. Total mortality was 100% in cockerels within 6 days, but 60% in turkeys. Similar but milder clinical signs were found in the VCC with a total mortality of 13.3%. The VCT showed mild drop in feed and water consumption, and no mortality. All the challenged groups had significant (p & 0.05) loss of weight when compared with their controls. Necropsy showed that while the UCC had severe proventricular haemorrhages, intestinal and caecal tonsil ulcers, the UCT had no digestive tract lesion. There was severe atrophy of the lymphoid organs in all the challenged groups. Histopathological sections of the bursa, spleen and thymus in all the challenged groups with special emphasis on the vaccinated and unvaccinated turkeys with mortalities of 0 and 60%, respectively, had very severe necrosis and depletion of the lymphoid tissue. Virus was isolated from the cloacal swabs. The haemagglutination inhibition antibodies were significantly higher (p & 0.05) in the challenged groups than the unchallenged. The above observations in the intestinal tracts of UCT are of diagnostic significance while the gross and microscopic lesions in the UCT and VCT show that La Sota vaccination may not protect turkeys against the destruction of the lymphoid organs by vND as earlier reported in chickens. This may lead to immunosuppression and production problems in areas where vND is enzootic.
机译：该项目的目的是研究商业火鸡的临床症状和病变，以及在商业火鸡中的培养基疾病（VND），并找出LA SOTA疫苗接种是否为这些标志和病变提供了保护。公鸡被包含为阳性对照。一百二十二十个火鸡泥和公鸡分为八组，如下：未接受的挑战火鸡（UUT），未被移出的挑战火鸡（UUT），接种疫苗的火鸡（VUT），接种挑战的火鸡（VCT），以及沿着同一条线，公鸡群是UUC，UCC，VUC和疫苗接种的挑战公鸡（VCC）。疫苗接种在3周龄，而挑战在6周龄。未接种的火鸡和公鸡（UCC和UCC）显示出不同程度的抑郁程度，腹泻和后来在挑战下瘫痪。在6天内，总死亡率为100％，但火鸡的60％是60％。在VCC中发现了类似但较高的临床症状，总死亡率为13.3％。 VCT显示出饲料和耗水量轻度下降，也没有死亡率。与对照组相比，所有挑战的群体都具有显着（P＆amp; 0.05）重量损失。尸检表明，虽然UCC具有严重的吞吐量出血，肠道和粘膜扁桃体溃疡，但UCT没有消化道病变。所有挑战的群体中淋巴器官的严重萎缩。所有挑战群体中Bursa，脾脏和胸腺的组织病理学部分，特别强调疫苗的疫苗和未被移植的火鸡，分别具有0％和60％的疫苗，具有非常严重的坏死和淋巴组织的枯竭。病毒与枝颈拭子分离。在挑战的团体中，血凝凝血抑制抗体显着高于（P＆amp; 0.05）。上述UCT肠道中的观察结果具有诊断意义，而UCT和VCT中的总和和微观病变表明，La SOTA疫苗接种可能不会保护火鸡免受鸡鸡的淋巴结破坏淋巴器官。这可能导致VND eNzootic的区域的免疫抑制和生产问题。

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