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首页> 外文期刊>Tropical Animal Health and Production >Prion protein gene polymorphism in four West African sheep populations
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Prion protein gene polymorphism in four West African sheep populations

机译：西非四个绵羊种群的on病毒蛋白基因多态性

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摘要

A total of 162 individuals, belonging to three Burkinab, and one Niger sheep populations, were analysed for prion protein (PrP) gene polymorphism at codons 136, 154 and 171. The ARQ allele was the most frequent in both the Burkinab, (86.7%) and the Niger (67.5%) sheep populations. The highly sensitive allele VRQ was not found in the sampled individuals. The highly resistant ARR allele was in very low frequency in the Burkina-Sahel (4.4%) and Mossi (3.2%) populations and was not present in the Djallonk, and Touareg populations. Only 4 out of 15 possible PrP genotypes were identified in the sampled individuals. No favourable ARR/ARR genotypes were found in either of the breeds. Sequencing a subgroup of the samples allowed the identification of other five polymorphisms on the PrP gene sequence at codons 116, 138, 151, 237 and 240. The very low frequency of the ARR allele in the West African sheep should dissuade the implementation of a preventive selection programme aimed to increase resistance to scrapie, to avoid an extreme erosion of the genetic stock.
机译：共分析了162个个体，分别属于三个布基纳法索和一个尼日尔羊种群，分别对136、154和171位密码子的病毒蛋白（PrP）基因多态性进行了分析。ARQ等位基因在布基纳法索中最常见，占86.7％。 ）和尼日尔（67.5％）的绵羊种群。在采样的个体中未发现高度敏感的等位基因VRQ。在布基纳-萨赫勒（4.4％）和莫西（3.2％）人群中，高抗性ARR等位基因的频率非常低，在Djallonk和Touareg人群中不存在。在抽样的个体中，仅在15种可能的PrP基因型中鉴定出4种。在两个品种中均未发现有利的ARR / ARR基因型。对样品的一个亚组进行测序可以鉴定出PrP基因序列上其他五个多态性，分别位于密码子116、138、151、237和240。西非羊中ARR等位基因的频率非常低，应该阻止采取预防措施选择方案旨在增加对瘙痒病的抵抗力，以避免遗传资源的极端侵蚀。

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