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首页> 外文期刊>Tropical Animal Health and Production >Clinicopathological studies on facial eczema outbreak in sheep in Southwest Turkey
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Clinicopathological studies on facial eczema outbreak in sheep in Southwest Turkey

机译：土耳其西南部绵羊面部湿疹暴发的临床病理研究

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After very hot summer, 22 sheep from 5 different flocks consisting of approximately 150-200 animals each were diagnosed with facial eczema in September 2005, in southwest Turkey. Photophobia, corneal opacity, severe ulcers of the facial skin, especially localized around the eyes and mouth, and 3% mortality were the most prominent clinical symptoms. GGT levels of the animals were very high and varying between 261- 328 U/l. While the activities of ALT and total bilirubin were elevated and AST was normal in affected sheep. Total bilirubin level was higher than normal. Seven of the 22 sheep were euthanatized and necropsy was performed on all of these animals. Severe icterus, hepatomegaly, enlarged gallbladder, congestion of mesenteric vessels were the common necropsy findings. Histopathological changes of the liver included necrosis of the hepatocytes, cholangiohepatitis characterized by mononuclear inflammatory cell infiltrate in the portal area and mild to severe fibrosis around bile ducts. A diagnosis of sporidesmin toxicosis was made based on the histopathology of the livers, the elevation in liver enzymes, and the development of cutaneous lesions consistent with photosensitization and high spore counts in the ruminal contents. Surviving sheep were treated with procaine penicillin + dihidrostreptomycin sulfate, multivitamin complexes and flunixin meglumine. Additionally, zinc sulphate was also given at a dose of 6 gr per 100 lt drinking water for 28 days. All treated sheep recovered. Pasture spore counts were between 96,300- 267,500 spores/g grass.
机译：炎热的夏天过后，2005年9月，在土耳其西南部，从5种不同的羊群组成的22只绵羊中，每只大约有150-200只动物被诊断出患有面部湿疹。畏光，角膜混浊，面部皮肤严重溃疡（尤其是眼和嘴周围局部溃疡）和3％的死亡率是最突出的临床症状。动物的GGT水平很高，在261-328 U / l之间变化。患病绵羊的ALT和总胆红素活性升高，AST正常。总胆红素水平高于正常水平。安乐死22只绵羊中的7只，对所有这些动物进行尸检。常见的尸检结果是严重的黄疸，肝肿大，胆囊肿大，肠系膜血管充血。肝脏的组织病理学变化包括肝细胞坏死，以门静脉区域浸润单核炎性细胞为特征的胆管性肝炎和胆管周围轻度至重度纤维化。根据肝脏的组织病理学，肝酶的升高以及与光敏化和瘤胃内容物中高孢子数一致的皮肤病变的发展，诊断出了孢子毒素中毒。用普鲁卡因青霉素+硫酸双歧链霉素，多种维生素复合物和氟尼辛葡甲胺治疗存活的绵羊。此外，每100升饮用水以6克的剂量给予硫酸锌28天。所有处理过的绵羊都康复了。牧草孢子数在96,300-267,500孢子/克草之间。

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