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首页> 外文期刊>Tropical Animal Health and Production >A potential camel reservoir for extended-spectrum beta-lactamase-producing Escherichia coli causing human infection in Saudi Arabia
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A potential camel reservoir for extended-spectrum beta-lactamase-producing Escherichia coli causing human infection in Saudi Arabia

机译：可能会产生广谱β-内酰胺酶的大肠杆菌的骆驼库可能在沙特阿拉伯引起人类感染

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摘要

The prevalence of antimicrobial resistance is continuing to increase. Consequently, efficient approaches to identify sources of resistance are required. This study aimed to compare Escherichia coli isolates from the intestinal tract of camels with isolates from human urinary tract infections (UTIs) in Al Ahsa Province, Kingdom of Saudi Arabia (KSA), for antimicrobial resistance and identification of extended-spectrum beta-lactamases (ESBLs). A microbiological study was conducted on 100 samples of cecal contents from camels and 100 urine samples from female UTI patients, to isolate and confirm E. coli using the VITEK 2 Automated System. Sensitivity patterns and identification of ESBLs were analyzed using the antimicrobial susceptibility test. Molecular techniques were used to detect E. coli drug-resistant clones. The presence rate of E. coli in camels was 26.0 % (n = 26/100), and in human samples, the rate of E. coli was 33.0 % (n = 33/100). ESBLs were reported for the first time in KSA, in 26.9 % (n = 5/26) of camel samples and 36.4 % (n = 8/33) of human samples. The multi-drug resistance (MDR) index was 0.13 and 0.17, for camels and humans, respectively. Escherichia coli drug-resistant O25b:H4-sequence type 131(ST131) clone was detected in two camel and two human isolates. This study demonstrates a high presence rate of ESBL-producing E. coli (ESBL-EC) in camels for the first time in KSA. Confirmation of MDR strains and E. coli ST131 clone in human and camel isolates suggests that camels could be a potential reservoir for resistant E. coli strains contributing to the increase in antimicrobial resistance in KSA.
机译：抗菌素耐药性的患病率持续增加。因此，需要有效的方法来识别抵抗源。这项研究旨在比较骆驼肠道中的大肠杆菌分离物与沙特阿拉伯王国（KSA）的Al Ahsa省（USA）的人尿道感染（UTI）分离物之间的抗药性和广谱β-内酰胺酶的鉴定（ ESBLs）。进行了一项微生物学研究，使用VITEK 2自动系统对骆驼的100种盲肠成分样品和女性UTI患者的100种尿液样品进行了分离和确认。使用抗菌药敏试验分析ESBLs的敏感性模式和鉴定。分子技术被用于检测大肠杆菌耐药克隆。骆驼中大肠杆菌的存在率为26.0％（n = 26/100），而在人类样品中大肠杆菌的存在率为33.0％（n = 33/100）。在KSA中首次报道了ESBL，其中骆驼样品占26.9％（n = 5/26），人类样品占36.4％（n = 8/33）。骆驼和人类的多药耐药性（MDR）指数分别为0.13和0.17。在两个骆驼和两个人类分离株中检测到了大肠杆菌耐药的O25b：H4序列131（ST131）型克隆。这项研究表明，骆驼首次在KSA中高产ESBL的大肠杆菌（ESBL-EC）。在人和骆驼分离物中对MDR菌株和大肠杆菌ST131克隆的确认表明，骆驼可能是耐药性大肠杆菌菌株的潜在库，这有助于增加KSA中的抗菌素耐药性。

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