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A vitamin for the brain

机译：大脑所需的维生素

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In the central nervous system (CNS) the function of retinoic acid, the active metabolite of vitamin A, is best understood from its action in guiding embryonic development; as development comes to completion, retinoic acid signaling declines. However, it is increasingly recognized that this signaling mechanism does not disappear in the adult brain but becomes more regionally focused and takes on new roles. These functions are often tied to processes of neural plasticity whether in the hippocampus, through homeostatic neural plasticity, the olfactory bulb or the hypothalamus. The role of retinoic acid in the control of plastic processes has led to suggestions of its involvement in neural disorders, both degenerative and psychiatric. This review presents a snapshot of developments in these areas over recent years.
机译：维生素A的活性代谢产物视黄酸在中枢神经系统（CNS）中的功能可从其指导胚胎发育的作用中得到最好的理解。随着开发的完成，视黄酸信号下降。但是，人们日益认识到，这种信号传导机制不会在成人大脑中消失，而是变得更加集中于区域，并发挥了新的作用。这些功能通常通过稳态神经可塑性，嗅球或下丘脑与海马神经可塑性过程相关。视黄酸在控制可塑性过程中的作用已提示其参与变性和精神病性神经疾病。这篇评论简要介绍了近年来这些领域的发展。

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