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首页> 外文期刊>Trends in Neurosciences >Harnessing plasticity to understand learning and treat disease
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Harnessing plasticity to understand learning and treat disease

机译:利用可塑性来了解学习和治疗疾病

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摘要

A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies suggest that cortical map plasticity is typically a transient phase that improves learning by increasing the pool of task-relevant responses. Here, I discuss a new perspective on neural plasticity and suggest how plasticity might be targeted to reset dysfunctional circuits. Specifically, a new model is proposed in which map expansion provides a form of replication with variation that supports a Darwinian mechanism to select the most behaviorally useful circuits. Precisely targeted neural plasticity provides a new avenue for the treatment of neurological and psychiatric disorders and is a powerful tool to test the neural mechanisms of learning and memory.
机译:大量证据表明神经可塑性有助于学习和疾病。最近的研究表明,皮层图可塑性通常是一个过渡阶段,通过增加与任务相关的反应池来改善学习。在这里,我讨论了关于神经可塑性的新观点,并提出了如何以可塑性为目标来重置功能障碍的电路。具体而言,提出了一种新模型,其中地图扩展提供了一种具有变异的复制形式,该变异支持达尔文机制来选择行为上最有用的电路。精确靶向的神经可塑性为神经和精神疾病的治疗提供了新途径,并且是测试学习和记忆的神经机制的有力工具。

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