Protein phosphatase 1 and memory: practice makes PP1 imperfect?

Waddell S

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Protein phosphatase 1 and memory: practice makes PP1 imperfect?

机译：蛋白磷酸酶1和记忆：实践会使PP1不完美吗？

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Long-lasting memories are most efficiently formed by multiple training sessions separated by appropriately timed intervals. A recent study revealed that expression of a transgene encoding an inhibitor of protein phosphatase 1 (PP1) in the forebrain enhanced memory formed during sub-optimal training. Thus, PP1 apparently constrains memory formation in the mouse. Furthermore, the report proposes that PP1 promotes forgetting.

机译：通过以适当的时间间隔分隔开的多个训练课程，可以最有效地形成持久的记忆。最近的一项研究表明，编码亚蛋白磷酸酶1（PP1）抑制剂的转基因在前脑中的表达增强了亚适度训练过程中形成的记忆。因此，PP1显然会限制小鼠的记忆形成。此外，报告建议PP1促进遗忘。

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《Trends in Neurosciences》 |2003年第3期|共3页
作者
Waddell S;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Memory; Phosphoprotein Phosphatase; Training; encoding; forgetting; 记忆; 磷蛋白磷酸酶;

机译：Memory;Phosphoprotein Phosphatase;Training;encoding;forgetting;记忆;磷蛋白磷酸酶;

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1. Protein phosphatase 1 and memory: practice makes PP1 imperfect? [J] . Waddell S Trends in Neurosciences . 2003,第3期

机译：蛋白磷酸酶1和记忆：实践会使PP1不完美吗？
2. Standardised extract of Bacopa monniera (CDRI-08) improves contextual fear memory by differentially regulating the activity of histone acetylation and protein phosphatases (PP1α, PP2A) in hippocampus [J] . PreethiJ., SinghH.K., VenkataramanJ.S., Cellular and Molecular Neurobiology . 2014,第4期

机译：Bacopa monniera（CDRI-08）的标准化提取物通过差异调节海马中的组蛋白乙酰化和蛋白磷酸酶（PP1α，PP2A）的活性来改善背景恐惧记忆
3. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats [J] . RahmanA., KhanK.M., Al-KhalediG., Neurotoxicology . 2012,第3期

机译：海马丝氨酸/苏氨酸蛋白磷酸酶PP1和PP2A的过度活化与幼鼠铅诱导的学习和记忆障碍有关
4. Interaction of cofilin with the serine phosphatases PP1 and PP2A in normal and neoplastichuman T lymphocytes [C] . Yvonne Samstag, Gabriele Nebl International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：Cofilin与丝氨酸磷酸酶pp1和pp2a的相互作用在正常和neoplastichuman t淋巴细胞中的pp1和pp2a
5. glc7-E101Q is a novel tool for integrated genomic and proteomic analysis of PP1/Glc7 phosphatase functional networks in Saccharomyces cerevisiae [D] . Szapiel, Nicolas 2007

机译：glc7-E101Q是用于酿酒酵母中PP1 / Glc7磷酸酶功能网络的基因组和蛋白质组学综合分析的新型工具
6. PP1 phosphatase-binding motif in Reg1 protein of Saccharomyces cerevisiae is required for interaction with both the PP1 phosphatase Glc7 and the Snf1 protein kinase [O] . Shadi Tabba, Simmanjeet Mangat, Rhonda McCartney, -1

机译：需要在酿酒酶GLC7和SNF1蛋白激酶的相互作用所需的PP1磷酸酶结合基序中的酿酒酵母酿酒酵母。
7. Estrés agudo en ratas y su efecto en la adquisición, consolidación y extinción de la memoria espacial: papel de la proteína quinasa erk1/2 y de las proteínas fosfatasas pp1 y pp2b en el hipocampo / Acute stress in rats and their effect on acquisition, consolidation and extinction ofudspatial memory: rol of the protein kinase ERK1/2 and protein phosphatases PP1 and PP2B in hippocampus [O] . Ortiz Montero Paola 2011

机译：大鼠急性应激及其对空间记忆的获得，巩固和消退的影响：蛋白激酶erk1 / 2和磷酸酶蛋白pp1和pp2b在大鼠海马/急性应激中的作用及其对获得，巩固的影响和你的灭绝空间记忆：蛋白激酶ERK1 / 2和蛋白磷酸酶pp1和pp2B在海马中的作用

Protein phosphatase 1 and memory: practice makes PP1 imperfect?

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