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首页> 外文期刊>Trends in Neurosciences >Bursts as a unit of neural information: selective communication via resonance.
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Bursts as a unit of neural information: selective communication via resonance.

机译:突发作为神经信息的一个单元:通过共振进行选择性通信。

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摘要

What is the functional significance of generating a burst of spikes, as opposed to a single spike? A dominant point of view is that bursts are needed to increase the reliability of communication between neurons. Here, we discuss the alternative, but complementary, hypothesis: bursts with specific resonant interspike frequencies are more likely to cause a postsynaptic cell to fire than are bursts with higher or lower frequencies. Such a frequency preference might occur at the level of individual synapses because of the interplay between short-term synaptic depression and facilitation, or at the postsynaptic cell level because of subthreshold membrane potential oscillations and resonance. As a result, the same burst could resonate for some synapses or cells and not resonate for others, depending on their natural resonance frequencies. This observation suggests that, in addition to increasing reliability of synaptic transmission, bursts of action potentials might provide effective mechanisms for selectivecommunication between neurons.
机译:与单个尖峰相反,生成尖峰突发的功能意义是什么?主要观点是需要突发来增加神经元之间通信的可靠性。在这里,我们讨论另一种假设,但又是互补的假设:具有特定的共振尖峰频率的脉冲比具有较高或较低频率的脉冲更有可能引起突触后细胞着火。由于短期突触抑制和促进之间的相互作用,这种频率偏爱可能发生在单个突触的水平,或者由于阈值以下的膜电位振荡和共振,可能发生在突触后的细胞水平。结果,相同的爆发可能会针对某些突触或细胞产生共振,而不会针对其他突触或细胞产生共振,这取决于它们的自然共振频率。该观察结果表明,除了增加突触传递的可靠性外,动作电位的爆发还可能为神经元之间的选择性通讯提供有效的机制。

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