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首页> 外文期刊>Trends in Neurosciences >News on glutamate receptors in glial cells.
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News on glutamate receptors in glial cells.

机译:关于神经胶质细胞谷氨酸受体的新闻。

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摘要

Glutamate (Glu) receptors convey most of the excitatory synaptic transmission in the mammalian CNS. Distinct Glu-receptor genes and different subtypes of glutamate-activated channels are expressed ubiquitously throughout the developing and mature brain in the two major macroglial cell types, astrocytes and oligodendrocytes. These glial receptors are found in acutely isolated cells and in brain slices, and are therefore functional in vivo. Glutamate receptors in glial cells are activated during neuronal activity, and their activation modulates gene expression in astrocytes and oligodendrocytes. The proliferation and differentiation of glial precursor cells are also regulated by activation of Glu receptors, suggesting that the excitatory transmitter might be one of the environmental signals that regulate glial-cell development.
机译:谷氨酸(Glu)受体在哺乳动物中枢神经系统中传递大多数兴奋性突触传递。在两种主要的大胶质细胞类型,星形胶质细胞和少突胶质细胞中,在整个发育中和成熟的大脑中普遍存在不同的Glu受体基因和不同类型的谷氨酸激活通道。这些神经胶质受体存在于急性分离的细胞和脑切片中,因此在体内具有功能。在神经元活动期间,神经胶质细胞中的谷氨酸受体被激活,它们的激活调节星形胶质细胞和少突胶质细胞中的基因表达。胶质前体细胞的增殖和分化也受到Glu受体激活的调节,这表明兴奋性递质可能是调节胶质细胞发育的环境信号之一。

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